Chithandizo chatsopano cha Alzheimer's chikuvomerezedwa ndi FDA

A latsopano Chithandizo cha Alzheimer's kumabweretsa chiyembekezo kwa anthu mamiliyoni ambiri okhudzidwa ndi matendawa. A FDA adavomereza posachedwapa Kisunla(donanemab-azbt) kwa akuluakulu omwe ali ndi matenda a Alzheimer's. Chivomerezo ichi ndi a kupita patsogolo kwakukulu polimbana ndi Alzheimer's, kupereka njira yatsopano yothandizira kuchepetsa kukula kwa matendawa.

Kodi matenda a Alzheimer ndi chiyani?

Alzheimer's ndi matenda a ubongo zomwe zimakhudza anthu mamiliyoni ambiri padziko lonse lapansi. Zimalepheretsa kukumbukira kukumbukira komanso kuganiza molakwika, ndipo pamapeto pake zimasokoneza zochita za tsiku ndi tsiku. Uwu ndi mtundu wofala kwambiri wa dementia ndipo umakhudza anthu okalamba. Matendawa amadziwika ndi kupangika kwa zolembera za beta amyloid ndi ulusi wopindika muubongo, zomwe zimayambitsa vuto la kukumbukira, kusokonezeka, ndi kusintha kwamakhalidwe.

Zizindikiro ndi kakulidwe

Zizindikiro zoyamba ndi zovuta kukumbukira posachedwa information ndi kumva kusokonezeka. Matendawa akamakula kwambiri, amayambitsa vuto la chinenero, kusokonezeka maganizo kwambiri, kusintha maganizo ndi khalidwe, ndiponso kutayika kwa luso la magalimoto. Zizindikirozi zimapangitsa moyo watsiku ndi tsiku kukhala wovuta kwa omwe akukhudzidwa.

FDA imavomereza chithandizo chatsopano cha matenda a Alzheimer's

Pa Julayi 6, 2024, a FDA idavomereza Kisunla (donanemab-azbt) pochiza akuluakulu omwe ali ndi matenda a Alzheimer's oyambilira. Mankhwalawa, opangidwa ndi Eli Lilly, amaperekedwa kudzera m'mitsempha ya mwezi uliwonse. Zawonetsedwa kuti zimachepetsa zolembera za beta amyloid mu ubongo, kuchepetsa kuchepa kwa chidziwitso ndi luso la ntchito. Chivomerezochi chimaphatikizapo anthu omwe ali ndi vuto lochepa la chidziwitso (MCI) ndi omwe ali ndi matenda oyambirira a Alzheimer's.

Kodi chithandizo chatsopano cha Alzheimer's chimagwira ntchito bwanji?

Kisunla ndi anti-amyloid anti monoclonal zomwe zimayang'ana zolembera za amyloid mu ubongo ndikuthandizira kuzichotsa. Mayesero azachipatala adawonetsa kuti odwala pa Kisunla anali ndi kuchepa pang'onopang'ono m'malingaliro ndi magwiridwe antchito poyerekeza ndi omwe ali pa placebo. Mankhwala amachepetsa kupita patsogolo kwachipatala ndi 35% ndipo ikupititsa patsogolo ntchito za tsiku ndi tsiku ndi 40% kwa odwala omwe ali ndi milingo yapakatikati ya tau, mapuloteni okhudzana ndi kuwonongeka kwa neuronal.

Zotsatira zamtsogolo

Kuvomerezedwa kwa Kisunla ndi sitepe yayikulu patsogolo kuchiza matenda a Alzheimer. Amapereka njira yatsopano yochizira yomwe ingapangitse moyo wabwino kwa odwala ndi mabanja awo. Kupita patsogolo kumeneku kukuwonetsa kufunikira kopitilira kafukufuku wopangidwa ndi mabungwe kuti apeze chithandizo chothandiza kwambiri.

Mayesero azachipatala ndi chitetezo

M'mayesero azachipatala, participnyerere zinayesedwa pogwiritsa ntchito mayeso osiyanasiyana monga Clinical Dementia Rating Scale (CDR-SB) ndi ADAS-Cog13 cognitive function test. Kisunla adachepetsa kuchuluka kwa tau mu cerebrospinal fluid ndi PET scan biomarkers. Ambiri mavuto anali zochita pa kulowetsedwa malo, mutu, ndi chizungulire. Panalinso zochitika za kutupa muubongo ndi magazi ang'onoang'ono muubongo, omwe ankayang'aniridwa mosamala. Chiwopsezo chokhala ndi zotsatira zoyipazi zitha kuyang'aniridwa ndi kuyang'anira koyenera.

Kuvomerezedwa ku European Union

Ngakhale Kisunla idavomerezedwa ndi FDA ku United States, sichinavomerezedwebe ku European Union. Pambuyo pa chivomerezo cha FDA, makampani opanga mankhwala nthawi zambiri amapempha chilolezo kuchokera ku mabungwe ena olamulira, monga European Medicines Agency (EMA), pamisika ina.

Kutsiliza

Kuvomereza kwa FDA kwa Kisunla ndichinthu chofunikira kwambiri pamankhwala a Alzheimer's, kupereka chiyembekezo kwa omwe akudwala matendawa. Chithandizo chatsopanochi chingachedwetse kukula kwa matenda ndikusintha moyo wa odwala. Kuti mudziwe zambiri information, chonde pitani ku FDA ndi Webusaiti ya Eli Lilly pamitu iyi.

Zokhudzana Zokhudzana

amagwira

amagwira

Zikubwera posachedwa 

Tikumaliza tsatanetsatane wa zida zathu zatsopano. Posachedwapa, tidzalengeza zosintha zonse. Ngati mukufuna kulandira nkhani zaposachedwa kwambiri pazamalonda athu, lembetsani ku nyuzipepala yathu kapena tsatirani njira zathu zapa media. 

Fomu Yamakalata

Lowani

Khalani infodziwani zaukadaulo wazogulitsa, machitidwe abwino, zochitika zosangalatsa ndi zina zambiri! Pambuyo polembetsa kalata yathu yamakalata, mutha kusiya kulembetsa nthawi iliyonse.

Fomu Yamakalata

Rushton mphepo

The Rushton impeller, yomwe imadziwikanso kuti flat disk impeller. Zinatuluka ngati njira yothetsera vutoli zovuta zosakanikirana ndi okosijeni mumakampani a biotechnology. Kapangidwe kake katsopano kadadziwika mwachangu chifukwa cha kuthekera kwake kotulutsa chipwirikiti, ndikupangitsa kuti ikhale muyezo mu gawoli kwazaka zambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika
Kukhathamiritsa kwa TECNIC

Pitch blade mphepo

Chigawochi ndi chofunikira kwambiri pakuwongolera kusakanikirana ndi kusamutsa anthu ambiri muzochita zama cell. Mapangidwe ake enieni amathandizira kugawa kofanana kwa zakudya ndi mpweya, zomwe ndizofunikira kuti ma cell azikhala ndi mphamvu komanso kukula pansi pamikhalidwe yabwino.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Rushton mphepo

Amadziwika ndi masamba ake ozungulira omwe amayikidwa molunjika ku shaft, the Rushton impeller imapangidwa kuti ipereke mitengo yometa ubweya wambiri komanso kubalalika kwabwino kwambiri kwa gasi, komwe kumakhala kothandiza kwambiri pazachilengedwe. Mu biotechnological ntchito zophatikiza mabakiteriya ndi yisiti, the Rushton impeller imapambana powonetsetsa kusakanikirana kofanana ndi kugawa bwino gasi, ngakhale m'zikhalidwe zokhala ndi kachulukidwe kwambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Cassette

Timamvetsetsa kufunikira kwa kusinthasintha komanso kuchita bwino munjira za labotale. Ndichifukwa chake zida zathu zidapangidwa kuti zizigwirizana nazo Cassette Mafayilo, yankho lapamwamba la ntchito zosiyanasiyana zosefera. Ngakhale sitipanga zosefera mwachindunji, makina athu amakometsedwa kuti agwiritse ntchito phindu lonse Cassette Zosefera zimapereka.

Cassette Zosefera zimadziwika chifukwa cha kusefera kwakukulu komanso kuchita bwino pakupatukana, kuwapanga kukhala abwino ultrafiltration, microfiltration, ndi nanofiltration ntchito. Mwa kuphatikiza zoseferazi mu zida zathu, timathandizira njira zofulumira komanso zogwira mtima, ndikuwonetsetsa kuti pakhale zotsatira zabwino kwambiri.

zida zathu, kukhala n'zogwirizana ndi Cassette zosefera, zimapereka kusinthasintha kwakukulu komanso kusinthasintha. Izi zikutanthauza kuti mutha kusankha fyuluta yomwe ikugwirizana ndi zosowa zanu zenizeni, kuwonetsetsa kuti kuyesa kulikonse kapena kupanga kumachitika mwachangu komanso molondola.

Kuphatikiza apo, zida zathu ndizodziwika bwino 100% automation luso. Pogwiritsa ntchito mavavu apamwamba kwambiri, timatsimikizira kuwongolera kolondola kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. izi automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kwambiri kulowererapo pamanja, kupanga makina athu odalirika komanso osavuta kugwiritsa ntchito.

Hollow Fiber

Timazindikira udindo wofunikira kwambiri wosinthika komanso wogwira ntchito bwino m'ma laboratories. Ichi ndichifukwa chake zida zathu zidapangidwa mwaluso kuti zizigwirizana nazo Hollow Fiber Mafayilo, kupereka yankho lapamwamba la ntchito zambiri zosefera. Ngakhale kuti sitimapanga zosefera izi mwachindunji, makina athu amawunikidwa bwino kuti agwiritse ntchito zonse zomwe angathe Hollow Fiber mafayilo.

Hollow Fiber Zosefera ndizodziwikiratu chifukwa chochita bwino kwambiri pakusefera bwino komanso kuchuluka kwake. Ndiwothandiza makamaka pamapulogalamu omwe amafunikira kuwongolera mofatsa kwa zitsanzo, monga mu chikhalidwe cha ma cell ndi njira zodziwika bwino za biomolecular. Pophatikiza zosefera izi ndi zida zathu, timathandiza njira zosefera bwino, zachangu, komanso zapamwamba kwambiri.

Chomwe chimasiyanitsa zida zathu ndi zake 100% automation luso. Pogwiritsa ntchito ma valve ofananira bwino, makina athu amawongolera mosamala kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. Level iyi ya automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kufunika koyang'anira pamanja, kupangitsa makina athu kukhala odalirika komanso osavuta kugwiritsa ntchito.

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