15 Epulo 2024

Ma bioreactor ogwiritsidwa ntchito kamodzi pamankhwala osankhidwa payekha

Kupita patsogolo kwamankhwala amunthu payekha ndi TECNIC Mayankho a Bioprocess

The TECNIC-BYOTIC mgwirizano wasankhidwa kuti ukhale gawo 1 la zogula zisanachitike zamalonda kuti apange nsanja yanzeru yogwiritsira ntchito ma bioreactors omwe amagwiritsidwa ntchito kamodzi motsatana, opangidwa kuti agwiritse ntchito autologous cell therapy. Vutoli lapadziko lonseli likukwezedwa ndi a Carlos III Health Institute (ISCIII) Ndi Center for Development of Industrial Technology (CDTI). Kusankhidwa uku kukuyimira kuzindikira kofunikira kwa luso laukadaulo komanso luso la UTE yathu, komanso gawo lofunikira pakupititsa patsogolo matekinoloje omwe amalola kupita patsogolo kwamankhwala amtundu wa cell.

Ma bioreactor ogwiritsidwa ntchito kamodzi Zatsopano chifukwa zimachotsa kufunika koyeretsa mobwerezabwereza ndi kutseketsa pakati pa magulu opanga, zomwe ndizofunikira kwambiri popanga chithandizo chamunthu payekha. Amachepetsanso kwambiri chiwopsezo cha kuipitsidwa ndikuwonjezera mphamvu zopangira pochepetsa kutsika pakati pamagulu.

Perfusion ndi kuwongolera kwapamwamba pakugwiritsa ntchito ma bioreactors amodzi

TECNIC Ntchito ya Bioprocess Solutions pakupanga ma bioreactor ogwiritsidwa ntchito kamodzi imaphatikizapo zapamwamba perfusion matekinoloje ndi njira zowongolera zotsogola, zofunikira pakukhathamiritsa kupanga kwa biopharmaceuticals kutengera automa cell a logous.

Ma bioreactors opangidwa ndi TECNIC phatikiza a perfusion dongosolo zomwe zimalola kudyetsa koyenera komanso kuchotsedwa kwa media mu chikhalidwe cha cell popanda kusokoneza malo osabala a riyakitala. Dongosololi ndilofunika kuti ma cell azitha kugwira ntchito nthawi yayitali yachikhalidwe. Ndiwofunikanso kwa autokupanga ma cell komwe kuli kofunikira komanso kuyera kwazinthu.

Kupitirira perfusion kumathandiza kukhalabe ndi mikhalidwe yabwino mkati mwa bioreactor, kugwirizanitsa zakudya ndikuchotsa zinyalala za metabolic zomwe zingalepheretse kukula kwa maselo kapena kusokoneza khalidwe la chinthu chomaliza. Izi zimatheka pogwiritsa ntchito zosefera zapamwamba za membrane zomwe zimalola kusankha passzaka za zakudya ndi kuchotsedwa kwa zinyalala, kuonetsetsa kuti maselo amasungidwa pamalo abwino kwambiri kuti achuluke ndi kusiyanitsa.

Kuwongolera ndi kuyang'anira mapulogalamu

Chimodzi mwazinthu zatsopano zamapangidwe a bioreactor ndikuphatikiza kwake ndi kuwongolera kwapamwamba software yomwe imayang'anira ndikuyang'anira mbali zonse zofunika za ulimi. Pulogalamuyi, yopangidwira makamaka ntchito zovuta za bioprocessing, imalola kuyang'anira nthawi yeniyeni ya magawo monga pH, kutentha, mpweya ndi mpweya wa carbon dioxide, kuchuluka kwa michere ndi metabolite, pakati pa ena.

Dongosolo lowongolera lili ndi mawonekedwe owoneka bwino omwe amathandizira kasamalidwe ka bioreactor, kulola ogwiritsa ntchito kusintha momwe zinthu zimachitikira mwachangu komanso molondola potengera zomwe zidachitika nthawi yeniyeni. Izi ndizofunikira kuwonetsetsa kuti njira yolima ikugwirizana ndi zomwe zimafunikira pagulu lililonse lopanga.

Kuphatikiza apo, pulogalamuyi imaphatikiza njira zophunzirira zamakina zomwe zimatha kuneneratu ndikusintha momwe amalimako kuti akwaniritse zotsatira za bioprocess. Kuthekera kodziwiratu kumeneku sikumangowonjezera kuchita bwino komanso kuchita bwino kwa biopharmaceutical kupanga, komanso kumachepetsa chiopsezo cha zolakwika za anthu ndikuwonjezera kubweza kwa magulu opanga.

Ubwino wampikisano, kuchepetsa mtengo, komanso kukhathamiritsa kupanga

Mapangidwe osinthika komanso osinthika a ma bioreactors amawalola kuti azitha kusintha masikelo osiyanasiyana opangira, kuyambira magulu ang'onoang'ono kuti afufuze mpaka pakupanga kwakukulu komwe kumafunikira pakugulitsa mankhwala. Kukhazikitsidwa kwa ma bioreactor ogwiritsira ntchito kamodzi kukuwonetsanso TECNICKudzipereka kwa machitidwe okhazikika, chifukwa amachepetsa kwambiri madzi ndi mphamvusumpoyerekezera ndi machitidwe ambiri ogwiritsira ntchito.

Ubwino wampikisano, kuchepetsa mtengo ndi kukhathamiritsa kupanga:

  1. Kuchepetsa kufunikira koyeretsa ndi kutseketsa: Ma bioreactor ogwiritsira ntchito kamodzi amachotsa kufunikira koyeretsa mobwerezabwereza ndi njira zotsekera pakati pa magulu, zomwe ndizokhazikika muzitsulo zosapanga dzimbiri. Kusinthaku kumachepetsa kwambiri kagwiritsidwe ntchito ka zinthu monga madzi, mphamvu, ndi mankhwala oyeretsera, komanso kumachepetsa kutha kwa zida, zomwe zimapangitsa kuti pakhale kusintha kwachangu pakati pa magulu opanga. Pochotsa njirazi, TECNIC sikungochepetsa kuwonongeka kwa chilengedwe komanso kumachepetsanso mtengo wokhudzana ndi zolowa ndi ntchito yofunikira pakukonza zida.

  2. Chiwopsezo chochepa cha kuipitsidwa: Ma bioreactors ogwiritsidwa ntchito kamodzi amapereka malo osabala ndi mapangidwe, kuchepetsa kwambiri chiwopsezo cha kuipitsidwa. Izi ndizofunikira kwambiri pakupanga mankhwala a biopharmaceutical, komwe kuipitsidwa kumatha kuwononga magulu athunthu, zomwe zimapangitsa kuti ndalama ziwonjezeke komanso kuchedwa kupanga. Kupititsa patsogolo chitetezo chazinthu sikungowonjezera ndalama zogwirira ntchito komanso kumateteza kukhulupirika kwa mtundu komanso kudalirika kwamakasitomala.

  3. Kuchulukitsa kusinthasintha kwa kupanga: Mapangidwe amtundu komanso kuphweka kwa kasinthidwe ka ma bioreactor ogwiritsira ntchito kamodzi amalola TECNIC kusinthira mwachangu masikelo osiyanasiyana opanga kapena kusinthana pakati pa mitundu yosiyanasiyana yazinthu popanda ndalama zowonjezera zida. Izi ndizofunikira pakuyankha moyenera zosowa zamsika komanso pakufufuza ndi kupanga ma biopharmaceuticals atsopano. Kutha kukulitsa kupanga popanda ndalama zambiri pazida zatsopano kumachepetsa CAPEX yofunikira pakukulitsa ndi kusiyanasiyana.

  4. Kuchita bwino kwa ntchito ndi kuchepetsa OPEX: Mwa kuphatikiza machitidwe apamwamba owunikira ndi kuwongolera, TECNIC kumawonjezera kupanga njira Mwachangu. Makinawa amachepetsa OPEX mwa kukhathamiritsa kugwiritsa ntchito zinthu ndikuwongolera mtundu wa chinthu chomaliza, kuchepetsa kutayika komanso kufunikira kwa kubwerezabwereza. Kuwunika kwa nthawi yeniyeni ndi kusintha kwa magawo ovuta kumapangitsanso kuti ntchitoyi ikhale yodziwikiratu komanso kuti isakhale ndi zolakwika zodula.

  5. Kupambana pamsika wapadziko lonse lapansi: Kuphatikizika kwa kuchepetsa mtengo, kuchulukirachulukira kwa kupanga, komanso kuwongolera malo abwino azinthu TECNIC monga mtsogoleri wampikisano pamsika wapadziko lonse wa biopharmaceutical. Ubwinowu umathandizira kampaniyo kupereka mayankho otsika mtengo komanso odalirika, kukopa makasitomala ambiri komanso kutsatira malamulo apadziko lonse lapansi opanga mankhwala.

Mgwirizano ndi chithandizo cha mabungwe

Chimodzi mwazopambana zazikulu za polojekitiyi zimachokera ku mgwirizano wamakono ndi mabungwe otsogola pazaumoyo ndi kafukufuku. Consortium iyi ikuphatikizapo AutoUniversity of Barcelona, ndi Catalan Blood ndi Tissue BankNdipo Chipatala cha Clinic ku Barcelona, iliyonse imathandizira luso lapadera lofunikira pothana ndi zovuta zaukadaulo ndi zamankhwala zomwe polojekiti yathu ikukumana nayo.

AutoNomous University of Barcelona (UAB)
Catalan Blood ndi Tissue Bank
Chipatala cha Clinic ku Barcelona
Carlos III Institute

Zotsatira zamtsogolo ndi masomphenya

Zotsatira za polojekitiyi zimapitirira kupititsa patsogolo kapangidwe kake kamankhwala. Imakhazikitsa mulingo watsopano wazinthu zatsopano zamtsogolo pazasayansi yazachilengedwe, zomwe zimayang'ana pamankhwala omwe samangotengera munthu payekha, komanso opangidwa bwino komanso mosatekeseka. Ndi polojekitiyi TECNIC ikutsogolera njira yopita ku tsogolo lomwe mankhwala opangidwa ndi munthu payekha si njira yokhayo, koma yotheka komanso yofikirika kwa onse, motsogozedwa ndi kupita patsogolo kwaukadaulo wa bioprocess.

Pulojekitiyi ikuwonetsa kudzipereka pakuwongolera mosalekeza komanso kuchita zinthu zatsopano. Kampaniyo ikukhazikitsa nsanja zatsopano zopangira autologous cell-based biopharmaceuticals, kuyimira mtundu wapadera wamankhwala wamunthu womwe umafunikira kusintha kwa maselo mwachindunji ndi wodwalayo. Izi sizongowonjezera njira zochiritsira, komanso zimakweza miyezo ya khalidwe ndi chitetezo pakupanga mankhwala.

Kuphatikiza apo, polojekitiyi imalimbikitsa kuphatikiza kwaukadaulo wapamwamba monga ma bioreactor osagwiritsa ntchito kamodzi, omwe ndi ofunikira kuti akwaniritse bwino njira zovuta za biotechnology. Zotukukazi cholinga chake ndi kuchepetsa kwambiri ndalama ndi nthawi zopangira, kupangitsa kuti chithandizo chapamwamba chikhale chopezeka komanso chowopsa. Pokwaniritsa zopititsa patsogolo izi, TECNIC sikungowonjezera kusintha kwamunthu kwa chithandizo chamankhwala, komanso kuyendetsa nthawi yatsopano yopezeka muzochita zamunthu payekha.

Pomaliza, TECNIC ikuthandizira ku chitukuko cha zachuma ndi zamakono polimbikitsa kulenga chidziwitso ndi kusamutsa teknoloji pakati pa maphunziro ndi mafakitale. Njira yogwirizirayi imatsimikizira kuti zatsopano zomwe zapangidwa mu labu zimafika pamsika, ndikusintha kafukufuku wapamwamba kukhala mayankho owoneka bwino omwe amapindulitsa anthu onse.

Zokhudzana Zokhudzana

amagwira

amagwira

Zikubwera posachedwa 

Tikumaliza tsatanetsatane wa zida zathu zatsopano. Posachedwapa, tidzalengeza zosintha zonse. Ngati mukufuna kulandira nkhani zaposachedwa kwambiri pazamalonda athu, lembetsani ku nyuzipepala yathu kapena tsatirani njira zathu zapa media. 

Fomu Yamakalata

Lowani

Khalani infodziwani zaukadaulo wazogulitsa, machitidwe abwino, zochitika zosangalatsa ndi zina zambiri! Pambuyo polembetsa kalata yathu yamakalata, mutha kusiya kulembetsa nthawi iliyonse.

Fomu Yamakalata

Rushton mphepo

The Rushton impeller, yomwe imadziwikanso kuti flat disk impeller. Zinatuluka ngati njira yothetsera vutoli zovuta zosakanikirana ndi okosijeni mumakampani a biotechnology. Kapangidwe kake katsopano kadadziwika mwachangu chifukwa cha kuthekera kwake kotulutsa chipwirikiti, ndikupangitsa kuti ikhale muyezo mu gawoli kwazaka zambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika
Kukhathamiritsa kwa TECNIC

Pitch blade mphepo

Chigawochi ndi chofunikira kwambiri pakuwongolera kusakanikirana ndi kusamutsa anthu ambiri muzochita zama cell. Mapangidwe ake enieni amathandizira kugawa kofanana kwa zakudya ndi mpweya, zomwe ndizofunikira kuti ma cell azikhala ndi mphamvu komanso kukula pansi pamikhalidwe yabwino.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Rushton mphepo

Amadziwika ndi masamba ake ozungulira omwe amayikidwa molunjika ku shaft, the Rushton impeller imapangidwa kuti ipereke mitengo yometa ubweya wambiri komanso kubalalika kwabwino kwambiri kwa gasi, komwe kumakhala kothandiza kwambiri pazachilengedwe. Mu biotechnological ntchito zophatikiza mabakiteriya ndi yisiti, the Rushton impeller imapambana powonetsetsa kusakanikirana kofanana ndi kugawa bwino gasi, ngakhale m'zikhalidwe zokhala ndi kachulukidwe kwambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Cassette

Timamvetsetsa kufunikira kwa kusinthasintha komanso kuchita bwino munjira za labotale. Ndichifukwa chake zida zathu zidapangidwa kuti zizigwirizana nazo Cassette Mafayilo, yankho lapamwamba la ntchito zosiyanasiyana zosefera. Ngakhale sitipanga zosefera mwachindunji, makina athu amakometsedwa kuti agwiritse ntchito phindu lonse Cassette Zosefera zimapereka.

Cassette Zosefera zimadziwika chifukwa cha kusefera kwakukulu komanso kuchita bwino pakupatukana, kuwapanga kukhala abwino ultrafiltration, microfiltration, ndi nanofiltration ntchito. Mwa kuphatikiza zoseferazi mu zida zathu, timathandizira njira zofulumira komanso zogwira mtima, ndikuwonetsetsa kuti pakhale zotsatira zabwino kwambiri.

zida zathu, kukhala n'zogwirizana ndi Cassette zosefera, zimapereka kusinthasintha kwakukulu komanso kusinthasintha. Izi zikutanthauza kuti mutha kusankha fyuluta yomwe ikugwirizana ndi zosowa zanu zenizeni, kuwonetsetsa kuti kuyesa kulikonse kapena kupanga kumachitika mwachangu komanso molondola.

Kuphatikiza apo, zida zathu ndizodziwika bwino 100% automation luso. Pogwiritsa ntchito mavavu apamwamba kwambiri, timatsimikizira kuwongolera kolondola kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. izi automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kwambiri kulowererapo pamanja, kupanga makina athu odalirika komanso osavuta kugwiritsa ntchito.

Hollow Fiber

Timazindikira udindo wofunikira kwambiri wosinthika komanso wogwira ntchito bwino m'ma laboratories. Ichi ndichifukwa chake zida zathu zidapangidwa mwaluso kuti zizigwirizana nazo Hollow Fiber Mafayilo, kupereka yankho lapamwamba la ntchito zambiri zosefera. Ngakhale kuti sitimapanga zosefera izi mwachindunji, makina athu amawunikidwa bwino kuti agwiritse ntchito zonse zomwe angathe Hollow Fiber mafayilo.

Hollow Fiber Zosefera ndizodziwikiratu chifukwa chochita bwino kwambiri pakusefera bwino komanso kuchuluka kwake. Ndiwothandiza makamaka pamapulogalamu omwe amafunikira kuwongolera mofatsa kwa zitsanzo, monga mu chikhalidwe cha ma cell ndi njira zodziwika bwino za biomolecular. Pophatikiza zosefera izi ndi zida zathu, timathandiza njira zosefera bwino, zachangu, komanso zapamwamba kwambiri.

Chomwe chimasiyanitsa zida zathu ndi zake 100% automation luso. Pogwiritsa ntchito ma valve ofananira bwino, makina athu amawongolera mosamala kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. Level iyi ya automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kufunika koyang'anira pamanja, kupangitsa makina athu kukhala odalirika komanso osavuta kugwiritsa ntchito.

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