Kodi dongosolo la TFF ndi chiyani ndipo limagwira ntchito bwanji?

M'nkhaniyi, tifotokoza mwatsatanetsatane zomwe TFF system (Tangential Flow Filtration) ndi yomwe imagwiritsidwa ntchito, ndikupereka chithunzithunzi cha ntchito zake, ubwino, zovuta komanso zamtsogolo.

Chidziwitso cha machitidwe a TFF

Tangential Flow Filtration ndi njira yapamwamba yomwe imagwiritsidwa ntchito kulekanitsa ndi kuyeretsa ma biomolecules, monga mapuloteni, maselo ndi zinthu zina zamoyo. Mosiyana mwachindunji kusefera, kumene otaya passes perpendicularly kupyolera mu fyuluta, mu TFF kuyenda passimakhazikika ku membrane pamwamba. Njira iyi imalola kuti pakhale zambiri imayenera kusefera ndondomeko, kuchepetsa kuchulukana kwa tinthu pa nembanembayo ndi kutalikitsa moyo wake.

Dongosolo la TFF ndilofunika makamaka pamagwiritsidwe ntchito komwe kuli kofunikira kusunga kukhulupirika kwa ma biomolecules komanso komwe kumafunikira kulekanitsa kwakukulu. Amagwiritsidwa ntchito m'ma laboratories ofufuza komanso kupanga mafakitale.

Mbiri ndi kusinthika kwa TFF

Kusefera kwa Tangential flow kunayambika mzaka za m'ma 1970 ndi 1980, makamaka pakuyeretsa mapuloteni komanso kulekanitsa ma cell m'ma laboratories ofufuza. Kuyambira pamenepo, TFF yasintha kwambiri ndipo yaphatikizidwa muzopanga zazikulu.

Poyambirira, ma nembanemba omwe amagwiritsidwa ntchito mu TFF anali osagwira ntchito komanso amakonda kuyipitsa. Komabe, ndi kupita patsogolo kwa sayansi ya zinthu ndi uinjiniya wa membrane, ma membrane olimba komanso ogwira mtima apangidwa. Kupita patsogolo kumeneku kwathandiza kuti machitidwe a TFF akhale chida chofunikira kwambiri pakuyeretsa ndi kuphatikizika kwa zinthu zachilengedwe, zomwe zikuthandizira kupanga mankhwala ochulukirapo achilengedwe ndi zinthu zina zaukadaulo.

Mitundu ya TFF Systems

Mitundu ingapo ya machitidwe a TFF adapangidwa kuti azigwiritsidwa ntchito ndi zosowa zosiyanasiyana

Ulusi wopanda pake
Cassette
ceramic
Flat module
Spiral cartridge

Kodi TFF imagwira ntchito bwanji?

Mu dongosolo la TFF, yankho limapopedwa tangentially pamwamba pa nembanemba ya fyuluta. Kuthamanga kumeneku kumapangitsa kuti tinthu ting'onoting'ono tiziyenda, kuchepetsa kuchulukana kwa nembanemba ndikuwongolera kusefera bwino. Njira ikhoza kukhala sumkusinthidwa mu njira zotsatirazi:

  1. Kukonzekera njira: Yankho lomwe lili ndi ma biomolecules kapena tinthu tating'ono topatulidwa timakonzedwa ndikuyikidwa mu dongosolo la TFF.
  2. Kupopa ndi kusefera: Yankho lake limapopedwa kudzera mu membrane module, pomwe kutuluka kwa tangential kumapangitsa kuti tinthu tiyambe kuyenda ndikulepheretsa kutsekeka kwa nembanemba.
  3. Permeate ndi kusunga zosonkhanitsa: Filtrate (permeate) imasonkhanitsidwa mu chombo cha permeate, pamene particles olekanitsidwa (osungira) amasonkhanitsidwa mu chotengera chosungira kuti apitirize kukonzanso kapena kutaya.

Kugwiritsa ntchito machitidwe a TFF

  1. Makampani azachipatala: kuyeretsedwa ndi kuchuluka kwa mapuloteni, ma antibodies ndi zinthu zina zamoyo. TFF ndiyofunikira pakupanga mankhwala achilengedwe, monga katemera ndi mankhwala a monoclonal, kuwonetsetsa chiyero choyenera komanso kuchuluka kwa zinthu zomaliza.
  2. umisiri: Kulekanitsa ndi kuyeretsedwa kwa maselo, mavairasi ndi zigawo zina zamoyo. Pakafukufuku wasayansi yazachilengedwe, TFF imagwiritsidwa ntchito popanga zitsanzo zenizeni komanso zokhazikika zamaphunziro ndi ntchito zosiyanasiyana.
  3. makampani Food: Kuchuluka kwa timadziti, mkaka ndi zakudya zina zamadzimadzi. Ma Flow filtrations amathandizira kukonza bwino komanso kukhazikika kwazakudya pochotsa zodetsa ndikuyika zomwe mukufuna.
  4. Kuchiza madzi: Kufotokozera ndi kuyeretsa madzi oipa ndi madzi akumwa. TFF imagwiritsidwa ntchito kuchotsa zonyansa ndi tinthu tating'onoting'ono m'madzi, kuwongolera mtundu wake ndikupangitsa kuti ikhale yoyenera kugwiritsidwanso ntchito kapena kuwononga.sumgawo.

Mitundu Yosefera

M'munda waukadaulo wazosefera, pali mitundu ingapo yomwe imagwiritsidwa ntchito kutengera kukula kwa tinthu tating'onoting'ono topatulidwa ndikugwiritsa ntchito:

Kuphatikiza
Kupangika
Kusinthika

Kutsiliza

In summary, tangential flow filtration (TFF) ndi njira yapamwamba yomwe imathandizira kuti ikhale yogwira ntchito kulekana ndi kuyeretsedwa ma biomolecules ndi particles. Chifukwa cha kapangidwe kake ndi kagwiritsidwe ntchito kake, kusefera kwa ma cross flow kwakhala chida chofunikira kwambiri muukadaulo wamakono wa biotechnology ndi mafakitale osiyanasiyana. Kuthekera kokhalabe ndikuyenda kosalekeza komanso kolamuliridwa, pamodzi ndi chiwopsezo chochepa cha kutsekeka, kumapangitsa machitidwe a TFF kukhala chisankho chokondedwa pamafakitale ambiri.

Ngati mumakonda dziko la biotechnology, Lumikizanani TECNIC gulu kwa malangizo ndi chithandizo posankha Zida zathu zambiri za TFF, zokhala ndi madera osefera kuyambira 0.1m² mpaka 36.3m²

Zokhudzana Zokhudzana

amagwira

amagwira

Zikubwera posachedwa 

Tikumaliza tsatanetsatane wa zida zathu zatsopano. Posachedwapa, tidzalengeza zosintha zonse. Ngati mukufuna kulandira nkhani zaposachedwa kwambiri pazamalonda athu, lembetsani ku nyuzipepala yathu kapena tsatirani njira zathu zapa media. 

Fomu Yamakalata

Lowani

Khalani infodziwani zaukadaulo wazogulitsa, machitidwe abwino, zochitika zosangalatsa ndi zina zambiri! Pambuyo polembetsa kalata yathu yamakalata, mutha kusiya kulembetsa nthawi iliyonse.

Fomu Yamakalata

Rushton mphepo

The Rushton impeller, yomwe imadziwikanso kuti flat disk impeller. Zinatuluka ngati njira yothetsera vutoli zovuta zosakanikirana ndi okosijeni mumakampani a biotechnology. Kapangidwe kake katsopano kadadziwika mwachangu chifukwa cha kuthekera kwake kotulutsa chipwirikiti, ndikupangitsa kuti ikhale muyezo mu gawoli kwazaka zambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika
Kukhathamiritsa kwa TECNIC

Pitch blade mphepo

Chigawochi ndi chofunikira kwambiri pakuwongolera kusakanikirana ndi kusamutsa anthu ambiri muzochita zama cell. Mapangidwe ake enieni amathandizira kugawa kofanana kwa zakudya ndi mpweya, zomwe ndizofunikira kuti ma cell azikhala ndi mphamvu komanso kukula pansi pamikhalidwe yabwino.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Rushton mphepo

Amadziwika ndi masamba ake ozungulira omwe amayikidwa molunjika ku shaft, the Rushton impeller imapangidwa kuti ipereke mitengo yometa ubweya wambiri komanso kubalalika kwabwino kwambiri kwa gasi, komwe kumakhala kothandiza kwambiri pazachilengedwe. Mu biotechnological ntchito zophatikiza mabakiteriya ndi yisiti, the Rushton impeller imapambana powonetsetsa kusakanikirana kofanana ndi kugawa bwino gasi, ngakhale m'zikhalidwe zokhala ndi kachulukidwe kwambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Cassette

Timamvetsetsa kufunikira kwa kusinthasintha komanso kuchita bwino munjira za labotale. Ndichifukwa chake zida zathu zidapangidwa kuti zizigwirizana nazo Cassette Mafayilo, yankho lapamwamba la ntchito zosiyanasiyana zosefera. Ngakhale sitipanga zosefera mwachindunji, makina athu amakometsedwa kuti agwiritse ntchito phindu lonse Cassette Zosefera zimapereka.

Cassette Zosefera zimadziwika chifukwa cha kusefera kwakukulu komanso kuchita bwino pakupatukana, kuwapanga kukhala abwino ultrafiltration, microfiltration, ndi nanofiltration ntchito. Mwa kuphatikiza zoseferazi mu zida zathu, timathandizira njira zofulumira komanso zogwira mtima, ndikuwonetsetsa kuti pakhale zotsatira zabwino kwambiri.

zida zathu, kukhala n'zogwirizana ndi Cassette zosefera, zimapereka kusinthasintha kwakukulu komanso kusinthasintha. Izi zikutanthauza kuti mutha kusankha fyuluta yomwe ikugwirizana ndi zosowa zanu zenizeni, kuwonetsetsa kuti kuyesa kulikonse kapena kupanga kumachitika mwachangu komanso molondola.

Kuphatikiza apo, zida zathu ndizodziwika bwino 100% automation luso. Pogwiritsa ntchito mavavu apamwamba kwambiri, timatsimikizira kuwongolera kolondola kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. izi automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kwambiri kulowererapo pamanja, kupanga makina athu odalirika komanso osavuta kugwiritsa ntchito.

Hollow Fiber

Timazindikira udindo wofunikira kwambiri wosinthika komanso wogwira ntchito bwino m'ma laboratories. Ichi ndichifukwa chake zida zathu zidapangidwa mwaluso kuti zizigwirizana nazo Hollow Fiber Mafayilo, kupereka yankho lapamwamba la ntchito zambiri zosefera. Ngakhale kuti sitimapanga zosefera izi mwachindunji, makina athu amawunikidwa bwino kuti agwiritse ntchito zonse zomwe angathe Hollow Fiber mafayilo.

Hollow Fiber Zosefera ndizodziwikiratu chifukwa chochita bwino kwambiri pakusefera bwino komanso kuchuluka kwake. Ndiwothandiza makamaka pamapulogalamu omwe amafunikira kuwongolera mofatsa kwa zitsanzo, monga mu chikhalidwe cha ma cell ndi njira zodziwika bwino za biomolecular. Pophatikiza zosefera izi ndi zida zathu, timathandiza njira zosefera bwino, zachangu, komanso zapamwamba kwambiri.

Chomwe chimasiyanitsa zida zathu ndi zake 100% automation luso. Pogwiritsa ntchito ma valve ofananira bwino, makina athu amawongolera mosamala kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. Level iyi ya automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kufunika koyang'anira pamanja, kupangitsa makina athu kukhala odalirika komanso osavuta kugwiritsa ntchito.

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