Novembala 30, 2023

Kodi Upstream ndi Downstream bioprocess?

Upstream ndi downstream bioprocess

At TECNIC, timazimvetsa mozama zonse ziwirizi upstream ndi downstream njira, ndizofunika kwambiri pakukula kwazinthu zachilengedwe. Chifukwa chake, nkhaniyi ikufuna kufotokozera kusiyana kwawo ndikuwunikira kufunikira kwawo mu biotechnology.

Upstream bioprocess

The upstream ndondomeko mu bioproduction ndizofanana ndi gawo la labotale ya chikhalidwe cha cell komwe mikhalidwe yabwino imakonzedwera kukula kwa maselo ndi kuchulukitsa.

Mu labotale, kuyesa kwa maselo kusanachitike ndikofunikira, motero, kukonzekera malo abwino kuti akule. Izi zimaphatikizapo kukonzekera sing'anga yopatsa thanzi, kusintha kutentha, ndikuwonetsetsa kuti ma cell ali ndi malo ndi zinthu zofunikira kuti akule ndi kuchulukana.

Mofananamo, mu upstream bioprocess mu bioproduction, zofunikira zopangira, pamenepa, tizilombo toyambitsa matenda, amakonzedwa ndi kulimidwa. Cholinga chake ndi kupanga malo abwino kuti akule ndi kuchulukitsa. Bioprocess iyi imaphatikizapo kukonzekera sing'anga ya chikhalidwe, kuthira tizilombo tomwe timafunikira, ndikuwongolera kukula ngati kutentha, pH, ndi mpweya, pakati pa ena, kuteteza t.ankafuna khalidwe la malonda ndi zokolola.

Monga momwe mu labotale ya chikhalidwe cha cell, komwe malo olamuliridwa komanso abwino akukula kwa maselo amakhazikitsidwa, ndi upstream bioprocess imakulitsa mikhalidwe yakukulira kwa tizilombo tating'onoting'ono komanso kupanga zinthu zomwe timafunikira pazachilengedwe. Bioprocess iyi ndiyofunikira pakuwonetsetsa kuti chinthu chomaliza chikufunika komanso zokolola zake.

1. Media Preparation
2. Kutentha
3. Chikhalidwe cha Maselo
4. Kuwunika ndi Kuwongolera

Downstream bioprocess

The downstream ndondomeko mu bioproduction amafanana kwambiri ndi gawo la labotale yamankhwala pomwe cholinga, kutsatira machitidwe angapo amankhwala, ndi kudzipatula ndi kuyeretsa pawiri zofunika kuchokera osakaniza a mankhwala ndi zosafunika.

The downstream bioprocess mu bioproduction imafanana kwambiri ndi gawo la labotale yamankhwala pomwe cholinga, kutsatira machitidwe angapo amankhwala, ndiye kuti alekanitse ndi kuyeretsa chinthu chomwe chikufunika kuchokera kumagulu ena osakaniza ndi zonyansa.

M'ma laboratories amankhwala, mukamaliza kuchitapo kanthu, njira monga kusefera kapena kuthirira zimalekanitsa ndikuyeretsa chidwi. Mwachitsanzo, kupeza mankhwala enaake kumafunika kulekanitsa zinthu zomwe mukufuna kuchita ndi zosafunika ndi zosafunika.

Mofananamo, bioproduction's downstream bioprocess imaphatikizapo kulekanitsa, kuyeretsa, ndi kuyika zinthu zazing'ono zomwe zimapangidwa panthawi ya upstream bioprocess. Chifukwa chake, pogwiritsa ntchito njira zosefera, siteji iyi imalekanitsa bwino zinthu zasayansi kuchokera ku zonyansa ndi tizigawo tating'ono tating'ono tating'onoting'ono, kutulutsa choyeretsedwa, mankhwala okhazikika omwe akonzeka kugwiritsidwa ntchito kapena kugulitsidwa.

Monga momwe kukwaniritsa pawiri koyera ndi cholinga mu labu mankhwala, ndi downstream bioprocess mu bioproduction ikufuna kupanga chopangidwa ndi biotechnological chapamwamba kwambiri, ndi chiyero choyenera ndi kuganizira, potero akuikonzekera kuti igwiritsidwe ntchito komaliza kapena magawo ena okonzekera ndi kusanthula.

1. Kuyeretsedwa
2. Kupatukana
3. Kunyamula
4. Kuletsa Khalidwe

Mawuwo

Kumvetsetsa kusiyana pakati upstream ndi downstream njira ndizofunikira kwambiri pakupanga bioproduction bwino. Pa TECNIC, ndife odzipereka kupititsa patsogolo luso la bioprocess ndi khalidwe lazogulitsa mkati mwa makampani opanga sayansi. Chifukwa chake, tikukupemphani kuti mupite ku webusayiti yathu ndi fufuzani mautumiki athu osiyanasiyana ndi mayankho ⇀ , zonse zidapangidwa kuti zikwaniritse zofuna zamakono za bioproduction.

Zokhudzana Zokhudzana

amagwira

amagwira

Zikubwera posachedwa 

Tikumaliza tsatanetsatane wa zida zathu zatsopano. Posachedwapa, tidzalengeza zosintha zonse. Ngati mukufuna kulandira nkhani zaposachedwa kwambiri pazamalonda athu, lembetsani ku nyuzipepala yathu kapena tsatirani njira zathu zapa media. 

Fomu Yamakalata

Lowani

Khalani infodziwani zaukadaulo wazogulitsa, machitidwe abwino, zochitika zosangalatsa ndi zina zambiri! Pambuyo polembetsa kalata yathu yamakalata, mutha kusiya kulembetsa nthawi iliyonse.

Fomu Yamakalata

Rushton mphepo

The Rushton impeller, yomwe imadziwikanso kuti flat disk impeller. Zinatuluka ngati njira yothetsera vutoli zovuta zosakanikirana ndi okosijeni mumakampani a biotechnology. Kapangidwe kake katsopano kadadziwika mwachangu chifukwa cha kuthekera kwake kotulutsa chipwirikiti, ndikupangitsa kuti ikhale muyezo mu gawoli kwazaka zambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika
Kukhathamiritsa kwa TECNIC

Pitch blade mphepo

Chigawochi ndi chofunikira kwambiri pakuwongolera kusakanikirana ndi kusamutsa anthu ambiri muzochita zama cell. Mapangidwe ake enieni amathandizira kugawa kofanana kwa zakudya ndi mpweya, zomwe ndizofunikira kuti ma cell azikhala ndi mphamvu komanso kukula pansi pamikhalidwe yabwino.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Rushton mphepo

Amadziwika ndi masamba ake ozungulira omwe amayikidwa molunjika ku shaft, the Rushton impeller imapangidwa kuti ipereke mitengo yometa ubweya wambiri komanso kubalalika kwabwino kwambiri kwa gasi, komwe kumakhala kothandiza kwambiri pazachilengedwe. Mu biotechnological ntchito zophatikiza mabakiteriya ndi yisiti, the Rushton impeller imapambana powonetsetsa kusakanikirana kofanana ndi kugawa bwino gasi, ngakhale m'zikhalidwe zokhala ndi kachulukidwe kwambiri.

Zokonzedwa Kwambiri
Mapulogalamu mu Biotechnology
Ubwino Wochita Mwachangu
Kukhalitsa ndi Kudalirika

Cassette

Timamvetsetsa kufunikira kwa kusinthasintha komanso kuchita bwino munjira za labotale. Ndichifukwa chake zida zathu zidapangidwa kuti zizigwirizana nazo Cassette Mafayilo, yankho lapamwamba la ntchito zosiyanasiyana zosefera. Ngakhale sitipanga zosefera mwachindunji, makina athu amakometsedwa kuti agwiritse ntchito phindu lonse Cassette Zosefera zimapereka.

Cassette Zosefera zimadziwika chifukwa cha kusefera kwakukulu komanso kuchita bwino pakupatukana, kuwapanga kukhala abwino ultrafiltration, microfiltration, ndi nanofiltration ntchito. Mwa kuphatikiza zoseferazi mu zida zathu, timathandizira njira zofulumira komanso zogwira mtima, ndikuwonetsetsa kuti pakhale zotsatira zabwino kwambiri.

zida zathu, kukhala n'zogwirizana ndi Cassette zosefera, zimapereka kusinthasintha kwakukulu komanso kusinthasintha. Izi zikutanthauza kuti mutha kusankha fyuluta yomwe ikugwirizana ndi zosowa zanu zenizeni, kuwonetsetsa kuti kuyesa kulikonse kapena kupanga kumachitika mwachangu komanso molondola.

Kuphatikiza apo, zida zathu ndizodziwika bwino 100% automation luso. Pogwiritsa ntchito mavavu apamwamba kwambiri, timatsimikizira kuwongolera kolondola kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. izi automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kwambiri kulowererapo pamanja, kupanga makina athu odalirika komanso osavuta kugwiritsa ntchito.

Hollow Fiber

Timazindikira udindo wofunikira kwambiri wosinthika komanso wogwira ntchito bwino m'ma laboratories. Ichi ndichifukwa chake zida zathu zidapangidwa mwaluso kuti zizigwirizana nazo Hollow Fiber Mafayilo, kupereka yankho lapamwamba la ntchito zambiri zosefera. Ngakhale kuti sitimapanga zosefera izi mwachindunji, makina athu amawunikidwa bwino kuti agwiritse ntchito zonse zomwe angathe Hollow Fiber mafayilo.

Hollow Fiber Zosefera ndizodziwikiratu chifukwa chochita bwino kwambiri pakusefera bwino komanso kuchuluka kwake. Ndiwothandiza makamaka pamapulogalamu omwe amafunikira kuwongolera mofatsa kwa zitsanzo, monga mu chikhalidwe cha ma cell ndi njira zodziwika bwino za biomolecular. Pophatikiza zosefera izi ndi zida zathu, timathandiza njira zosefera bwino, zachangu, komanso zapamwamba kwambiri.

Chomwe chimasiyanitsa zida zathu ndi zake 100% automation luso. Pogwiritsa ntchito ma valve ofananira bwino, makina athu amawongolera mosamala kusiyana kwa kuthamanga, kuthamanga kwa transmembrane, ndi kuthamanga kwa magazi. Level iyi ya automation sikuti imangowonjezera luso komanso kulondola kwa kusefera komanso kumachepetsa kufunika koyang'anira pamanja, kupangitsa makina athu kukhala odalirika komanso osavuta kugwiritsa ntchito.

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