22 Gunyana, 2023

Chemotherapy revolution pamwe nekusarudza kudzikiswa kwemazinga eplatinamu

Nzira itsva yekudzikisa mhedzisiro yechemotherapy

Chemotherapy chishandiso chakakosha mukurwisa cancer; zvisinei, kushandiswa kwayo kunowanzounza migumisiro isingadikanwi. Rimwe dambudziko guru ndere kuramba kwesimbi dzine chepfu, yakadai seplatinum (Pt2 +), muhutano hwevarwere mushure mekurapa. Masimbi anorema akadai anogona kukanganisa nhengo uye kukonzeresa mhedzisiro, kusanganisira nephrotoxicity, hepatotoxicity, uye neurotoxicity. Kugadzirisa dambudziko iri, Byotic yakapayona prototype inovimbisa, yakanyatsogadzirirwa kuchengetedza kwakasarudzika kwesimbi, ichinyanya kutarisisa platinamu. Naizvozvo, chirongwa ichi chine chinangwa che kuderedza chepfu platinum mazinga mushure mechemotherapy.

Itarisiro yekuvandudza ine yakasarudzika simbi yekuchengetedza

Chinangwa chikuru chepurojekiti iripo ndeyekutsvagisa uye kuyera kushanda kweiyo prototype mukuchengetwa kwesimbi, kuburikidza neapheresis, mumhuka dzine mapundu akaiswa chemotherapy. Iyo prototype inoratidzira a sarudza adsorbent column yeplatinamu (Pt2+), kushandisa adsorbent biomaterial.

Apheresis inzira yekusefa yeextracorporeal inoshandiswa kubvisa zvinhu zvisingadiwe kubva muropa. Pano, iyo prototype inotarisirwa kuchengetedza simbi dzinorema, kunyanya platinamu, inogona kunonoka post-chemotherapy. By kusarudza adsorbing izvi zvinorema simbi kuburikidza apheresis membrane, tariro ndeyekuderedza mhedzisiro yechemotherapy ine chekuita nekuvapo kwesimbi dzine chepfu mumuviri.

Chemotherapy ine simba rakaenzana uye yakaderedzwa chepfu

Kuitira kuzadzikisa chinangwa chikuru chepurojekiti, zvidzidzo zvepreclinical zvichaitwa pamamodeli enguruve. Kunyanya, zvidzidzo izvi zvine chinangwa chekuongorora adsorbent column's efficacy mukuderedza mazinga eplatinum eplasma.

Iyi purojekiti, inotsigirwa nemari pamwe chete neve Center for the Development of Industrial Technology (CDTI) yeSpain's Ministry of Economy and Competitiveness, inomiririra chiitiko chakakosha mukati ByoticR&D kuedza. Zvakadaro, nepo zvipingamupinyi zvakaita sekugadzira a porcine xenotransplant muenzaniso uye kugona kweapheresis mumhuka idzi kuri kumberi, iyi nzira inokatyamadza haingovimbisi kuvandudza hupenyu hwevarwere vegomarara asi zvakare kugadzira nzira yekurapa kunoshanda.

TECNIC uye Byotic parizvino vari kubatana kuita chirongwa chenyika pane bioreactors uye autologous masero.

 
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