Majekiseni anoshanda sei? Nhanganyaya kumajekiseni nemhando dzawo

Majekiseni ave a ibwe repakona mukusimudzira hutano hweveruzhinji, zvichipa dziviriro pazvirwere zvakawanda zvinotapukira. Chakakosha, jekiseni inhengo yebhayoloji inotevedzera hutachiona hwehutachiona, senge hutachiona kana bhakitiriya, asi hwakagadzirwa kuti risakonzere chirwere chacho. Kana yaunzwa mumuviri, inoita kuti immune system ikwidze mhinduro, ichiziva mumiriri seyekunze uye nekurangarira maitiro ekurwisa nayo zvinobudirira. Izvi zvinowanzoitika kuburikidza nekushandisa kwakasiyana zvikamu zvepathogen, senge utachiona husina simba kana kuuraya, muchetura hwahwo, kana imwe yemapuroteni ayo ari pamusoro. Iyi nzira ndiyo hwaro hwejekiseni uye inomiririra chimwe chezvakanyanya kubudirira mumunda wemishonga.

Nhoroondo yemajekiseni inotangira pakupera kwezana ramakore rechi 18 apo Edward Jenner vakagadzira mushonga wekutanga wakabudirira wekudzivirira chibhokisi. Kubva ipapo, majekiseni akashanduka zvakanyanya, nekufambira mberi kwehunyanzvi uye nekunzwisisa kwakadzama kweimmunology kuumba kukura kwavo. Nhasi, majekiseni haangodziviriri zvirwere chete asiwo anoita basa rakakosha muhurongwa hwehutano hwepasi rose, zvakanyanya kuderedza kuitika uye kuoma kwezvirwere zvinotapukira pasi rose.

Kushanduka kwemajekiseni

Sainzi yekudzivirira yakasimukira zvakanyanya, ichifambira mberi kubva kuhunyanzvi hwekushandisa utachiona husina simba kana kusashanda kune nzira dzepamusoro dzebiotechnological. Majekiseni ekare, kunyange akashanda, aive nemiganhu sezvinodiwa zvefiriji uye njodzi kune vanhu vasina kudzivirirwa. Nekunzwisisa kwakadzama mune immunology uye genetics, majekiseni ave akanyanya kuoma.

Recombinant DNA tekinoroji, semuenzaniso, yagonesa kugadzira majekiseni akachengeteka, anoshanda zvakanyanya munzvimbo dzakadzorwa dzemurabhoritari, sezvinoonekwa nejekiseni reHepatitis B. Nhanganyaya ye MRNA majekiseni inoratidza kumwezve shanduko, uchishandisa genetic zvinhu kukurudzira mhinduro dze immune kurwisa hutachiona. Uku kusimukira, kunyanya kuoneka panguva yeCOVID-19 denda, kunoratidza kufambira mberi nekukurumidza uye kuchinjika kwehunyanzvi hwemazuva ano hwekudzivirira.

Mhando dzakasiyana dzemajekiseni

Rarama Attenuated Vaccines
Majekiseni asingashandi
Subunit, recombinant, conjugate, uye Virus-Senge Particle
Majekiseni eDNA
Viral vector vaccines
MRNA majekiseni

Katalin Karikó: Mumwe piyona mumRNA Vaccine

Zvakapihwa naKatalin Karikó kumunda wemRNA tekinoroji yakabatsira mukugadzirwa kwemishonga yekudzivirira mRNA. Basa rake, rinowanzoitwa mukutarisana nekupokana kwakanyanya uye matambudziko emari, rakaisa hwaro hwekushandisa synthetic mRNA mumashandisirwo ekurapa. Tsvagiridzo yaKatalin Karikó yakanangana nekukunda matambudziko ane chekuita nemRNA, senge ayo kusagadzikana uye innate immunogenicity, kuchigadzira nzira yekushandiswa kwayo mumajekiseni.

Kubudirira kwemishonga yekudzivirira mRNA kurwisa COVID-19 chiratidzo chechiratidzo cheKarikó uye kutsungirira. Aya majekiseni haana kungoratidza kuti anoshanda zvakanyanya asi zvakare anomiririra paradigm itsva mukuvandudzwa kwejekiseni. Kugona kukurumidza kugadzira uye kugadzira majekiseni mukupindura utachiona huri kubuda hunogona kushandura maitiro edu kudzivirira nekudzora zvirwere zvinotapukira. Nhaka yaKarikó chiyeuchidzo chekukosha kwekutsvaga kwakakosha uye kugona kwehunyanzvi hwesainzi kugadzirisa matambudziko ehutano pasi rose.

Nguva itsva mukudzivirira uye hutano hweveruzhinji

Rwendo rwesainzi yekudzivirira kubva pakupinza majekiseni kuenda kunzira dzepamusoro dzemajini uye mamorekuru chiratidzo chekutsvaga kusinganeti kweruzivo uye hunyanzvi mune zvekurapa. Mishonga ine zvakachinja maitiro edu kuzvirwere zvinotapukira, kudzivirira zvirwere zvisingaverengeki uye kuponesa mamiriyoni evanhu. Shanduko kubva kumararamiro echinyakare akaremerwa uye akasashanda majekiseni kusvika kune akanyanya DNA uye mishonga yekudzivirira mRNA inoratidza kufambira mberi kunoshamisa kwakaitwa mubiotechnology uye immunology.

Remangwana rejekiseni rakajeka, nekutsvagisa nekuenderera mberi kunovimbisa nzira dzinoshanda, dzinokurumidza, uye dzemunhu dzekudzivirira nekurapa chirwere. Kufambira mberi mune tekinoroji yekudzivirira, kunyanya mumunda we mRNA uye DNA vaccine, inopa mikana mitsva yekurwisa kwete zvirwere zvinotapukira chete asiwo mamwe matambudziko ekurapa, akadai segomarara uye autoimmune disorders. Sezvo isu tichigamuchira iyi nguva itsva, kukosha kwejekiseni muhutano hweveruzhinji uye basa rehunyanzvi hwesainzi mukusimudzira hutano hwevanhu hucharamba huchikura.

Ongorora huwandu hwedu hwakakwana hwemidziyo

Ongorora kumberi kwerecombinant protein nemidziyo yedu yepamusoro. Yedu bioreactors yakagadzirirwa kushandiswa kwakasiyana, kuve nechokwadi chekushanda uye kunaka. Tsvaga yedu yakazara yakazara biotechnology mhinduro, kusanganisira Bioreactors, Tangential Flow Filtration masisitimu, nezvimwe. Shanyira mapeji edu e Bioreactors ⇀, Tangential Flow Sefa ⇀, uye Contact ⇀ kuti uwedzere information uye kubvunza.