TECNICMhinduro yekuchinja Cell Therapy

Mumamiriro ezvinhu ebiotechnology, nhanho dzakakosha dziri kuitwa muchizvarwa chinotevera sero uye gene kurapwa (CGTs) ⇀, ichipa nzira inotyisa ye kupindira kwekurapa kusati kwamboitika muvarwere vane mashoma ekurapa maitiro ezvimwe zvekurapa mamiriro nekupa munhu uye anonangwa nzira

Iyi tekinoroji nyowani, inodaidzwa kuti cell therapy, inotarisa pakupinzwa kwemasero matsva, ane hutano mumuviri nechinangwa chekuti. kutsiva vanorwara kana vakakuvara, kugadzirisa kushanda kwemasero omurwere kuburikidza nekutaura kwezvinhu, kana encompassing kubviswa kwemaseru asina kushanda nesimba uchishandisa immune masero. Iko kugona kwesero kurapa kumisa uye kudzosera zvirwere, kudzoreredza nhengo dzakakuvadzwa, uye pakupedzisira kurapa mamiriro ezvinhu anotyisidzira hupenyu iko zvino chave chinangwa chechokwadi chesainzi vanoshanda kumberi kwemushonga wekuvandudza. Zvisinei, kune zvinetso zvekukurumidza uye zvenguva refu zvinogona kuva dambudziko panguva yekugadzira maitiro emishonga iyi yekurapa.

Mukupindura, TECNIC upstream scalable cell kuwedzera bioreactors uye downstream kugadzirisa portfolio yetekinoroji inoita basa rakakosha mukutsigira kuwedzera kwesero, kukohwa, kugeza, uye kuisa pfungwa, nguva dzose zvichikubatsira kuwana kugadzirwa kwaunoda kubva. zviyero zveClinical Research kune Pilot uye Industrial Bioprocesses ⇀.

Chii chinonzi cell therapy?

Kubva pakuona kwekukura kwehupenyu, zvirwere mumuviri unorarama zvinowanzoratidza matambudziko muchikamu chekutanga chehupenyu hwayo: masero. Mupfungwa iyi, cell therapy ishoko rakakura iro encompasses the kushandiswa uye kusiyanisa marudzi akasiyana-siyana emasero, kazhinji masero ane simba rakawanda, semushonga wekurapa iyo inopa mhedzisiro inoshamisa kune varwere vanoda nzira nyowani dzekurapa. Chinangwa chikuru cherudzi urwu rwebiotherapy ndechekugadzira mishonga yekurapa uye nzira dzekurapa kugadzirisa uye kukurudzira nyama uye nhengo dzakakuvadzwa kana, zvakare, kurapa zvirwere nemamiriro ezvinhu zvakadai sezvirwere zvemapapu, neurodegenerative disorders, autozvirwere zvekudzivirira zvirwere zvemuviri uye zvirwere zvakadai sevakuru-kutanga leukemia, Hodgkin's lymphoma, kana acute myeloblastic leukemia (AML)

Muenzaniso mukuru wekushandiswa kwayo kushandisa induced pluripotent stem masero (iPSC masero) kupa isina muganho T cell sosi yeCAR T cell therapy yekuvandudza, iyo inosanganisira reprogramming T-masero emurwere kunanga uye kuparadza chaiwo maantigen egomarara. Uku kusanganiswa kweIPSC neCAR tekinoroji inopa mukana unoshamisa kune oncology uye inomhanyisa zvakanyanya kuvandudzwa kwesero-based therapy yevarwere vegomarara.

Kubatsira kweiyi biotherapy ndeyekuti inogona kuva munhu zvichienderana kurapa chaiyo yemunhu pathologies. Uyezve, kutevera principle "Primum non nocere" (kutanga usakuvadza) uye uchifunga kuti kugadzirisa masero kunoitika mumuviri wemunhu, cellular therapy inoonekwa seyakachengeteka, isina kana mishoma mhedzisiro inoonekwa mumhuka dzakawanda uye dzevanhu preclinical uye zvidzidzo zvekiriniki. .

Mishonga yemasero uye basa rinoshanduka remushonga wemunhu

Iwe pachako mushonga inzira itsva yekudzivirira zvirwere nekurapa iyo inofunga kusiyana kwemabatiro anoita vanhu pamushonga kuitira kuti vape "kurapa kwakakodzera panguva chaiyo". Mushure mekubvumidzwa mumiedzo yekurapa, kufambira mberi kwakaitwa mukurapa kwemunhu kwakatotungamira kune zvitsva zvine simba zvakawanikwa uye marapirwo akatenderwa anokwenenzverwa kune chaiwo hunhu hwevanhu.

Mukati meiyi paradigm, allogenic uye autologous cell therapies inobuda senzira dzinovimbisa:

Autologous cell therapy

Allogenic cell therapy

Scale-up vs Scale-out maitiro

Matambudziko musero kurapwa

Mishonga yemasero iri kuvandudzwa uye inobata chivimbiso chikuru chekurapa huwandu hwezviratidzo zvechirwere. Nekudaro, kune nekukurumidza uye kwenguva refu matambudziko ekukunda ayo anogadzira zvipingamupinyi panguva yekugadzirwa kweaya ekurapa maitiro:

Zvinetso zvekugadzira

Scalability matambudziko

Mutengo wematambudziko ekugadzira

Advanced Bioreactors

Mukupindura matambudziko aya, TECNIC zvave automatic bioprocess midziyo yezvose zviri zviviri upstream uye downstream budiriro. Isu tinonzwisisa kuti, kusiyana nekugadzirwa kwechinyakare biotech (senge maAbs uye mamwe biologics), kugadzirwa uye kugadzirisa kwekurapa uku kunoda kuti nharembozha ichengetedze yakakosha hunhu (CQAs) yakafunga maitiro ese.

Nechikonzero ichocho, TECNIC eLAB® ⇀ , ePILOT® ⇀ uye ePROD® ⇀ ma bioreactors akagadzirirwa kuve nechokwadi chemhando yepamusoro uye mhedzisiro yekukunda matambudziko ambotaurwa. Isu tinopa yakanakisa bioprocess mhinduro yemasero ekurapa, sezvo midziyo yedu yakanyatsogadzirwa kuti ipe kutonga kwakaringana pamusoro pezvakatipoteredza parameter, optimizing cellular mamiriro kuti maximal goho uku ichideredza zviwanikwa uye nguva kushandiswa. Uyezve, midziyo yedu yakagadzirwa ne automatic unit control iyo inosanganisira yakabatanidzwa data analytics masisitimu, iyo inogonesa iwe kukwenenzvera mamiriro etsika kuti ugadzire yakatsetseka bioprocess kuita.

Yepamberi Bioreactor Solutions ⇀

Tangential Flow Filtration mune cell therapy

Yakawanda yekutsvagisa nekusimudzira bioprocesses yesero uye gene kurapwa (CGTs) yakatarisana nekuwedzerwa kweiyo upstream urongwa. Nepo R&D ichifanirwa kuenderera mberi ichitarisa mukuvandudza kusimba kwesero uye zvimwe zvinodiwa zvekuwedzera masero, bhodhoro rekugadzira riri kutsamira kune downstream processing. Kuti tigadzirise chinodiwa ichi nehupamhi hwepamusoro uye hukuru hwepamusoro, yedu eLAB® TFF ⇀, eLAB® TFF SU ⇀, ePILOT® TFF ⇀ uye ePROD® TFF ⇀ kupa mhinduro inogona kuva yakayerwa, autoyakabatana, yakazara uye inogamuchirika kugadzirisa mabasa ebudiriro. Kunyangwe iwe uri kuita zvekupayona kutsvagisa kana kutyaira maindasitiri-chikero kugadzirwa, tigonese kusangana nemagumo ako ekugadzira mapurojekiti ako ekurapa maseru.

Kuti ave nechokwadi chekuti kufambira mberi mukati upstream processing inowedzerwa, TECNIC midziyo zvakare inovimbisa kushanda downstream kugadzirwa kwemaitiro ekuderedza vhoriyamu, kugeza uye kugadzirwa kwechigadzirwa chekupedzisira. Panguva imwecheteyo, the autokugadzirwa kwemidziyo yedu recipes inoderedza zvakanyanya kukosha kwekugadzirisa manyore, kuwedzera kushanda kwevashandisi uye kuderedza mari yevashandi. Uyezve, isu tinogonesa iwe kuve nepamusoro peprotein clearance, kudzoreredza kwakanyanya kwemaseru anoshanda ane kushomeka kwekuita kwayo.

Yepamberi Tangential Flow Filtration Solutions ⇀

Nyaya dzekubudirira uye maapplication

Tichifunga nezvekuoma kweiyo bioprocess, zvinouya zvisingashamisi mutengo unozivikanwa unodhura weizvi biotherapies. In TECNIC tinoda kubatsira vatengi vedu kugadzira therapy cell inowedzera scalable uye, saka, inowanikwa kune varwere. Sezvinoita chero tekinoroji nyowani, mutengo unouya nekufamba kwenguva nehunyanzvi hwekuvandudza uye, nepo isu tisingakwanise kupa ruzivo rwakakwana nekuda kwekuvanzika, kwave nezviitiko zvakawanda apo. TECNICMidziyo yemidziyo yakawedzera zvakanyanya kugadzirwa kwemishonga iyi.

Nezvedu zvizere automatic bioreactor eLAB® Advanced uye nekuda kwekumisikidzwa kwayo kwakawanda (kusvika gumi nemaviri ezvikepe zvakazvimirira zvakazara), mumwe wevatengi vedu ari kuita kusimudzira kukuru kwe autologous cell therapy yekutsiva yakakuvadzwa mwongo mushure mekushongedza kenza kurapwa. Kuziva kuti, sekunge chero rudzi rwesero therapy, iyo yekupedzisira-chigadzirwa mhando uye huwandu hunoenderana nehuwandu hwekutanga hweT masero akagadziridzwa uye akawedzera ex vivo, uyu mutengi chaiye aive nezvikuru zviviri zvakakosha zvinodiwa:

Nekuda kwekuda kwakashata kwekuenderana, murwere wese T masero akabatidzwa kuti akonzere ex vivo kuwedzera kunodiwa kubva kune yakasarudzika bioreactor tsika.

Zvakare, nekuti murwere wavo anowanzo kurwara zvakanyanya, T masero avo anowanzo kura, akasiyaniswa uye anogona kunge akaremedza kukura, saka mutengi wedu aifanira kukwanisa wedzera sero mumamiriro ezvinhu akaoma kwazvo.

Kuti tigutse aya mapoinzi maviri, isu takakurudzira mutengi wedu iyo eLAB® Advanced ⇀. Nekuda kwemidziyo iyi, yakagadzirwa nekusiyana-siyana mupfungwa, bioreactor yedu yakavapa simba rekusimudzira nehupamhi hwepamusoro uye kudzora huwandu hukuru hweakasiyana T cell tsika dzevarwere vavo, zvichivagonesa kugadzirisa tsika yavo mamiriro vachishandisa automatic control unit inodzorwa neindasitiri PLC. Nayo, vakakwanisa kuve nekutonga kwakazara pamusoro peakakosha paramita - senge tembiricha, pH, yakanyungudika okisijeni, uye agitation kumhanya - anosvika gumi nemaviri akazvimirira akazvimirira ega evarwere panguva imwe chete nekuvimbika uye kugona.

Uyu mutengi mumwechete, achiona zvakapfuura zvakanaka mhedzisiro ne TECNIC midziyo uye rubatsiro, akasarudza kuwedzera-up imwe yemaitiro avo ekare ekushanda ane allogenic therapies, ayo akagadzirwa mumabheji makuru kubva kune asina hukama evanopa tishu akadai semwongo wemapfupa. Kuti vaite kuti allogenic cell therapy iwanikwe kune varwere, yavo logistics uye mutengo zvidzidzo zvaida autokugadzirwa kwemamatic mutsika dze50 L.

 

Tichifunga nezvekuoma kweiyo bioprocess, zvinouya zvisingashamisi mutengo unozivikanwa unodhura weizvi biotherapies. In TECNIC tinoda kubatsira vatengi vedu kugadzira therapy cell inowedzera scalable uye, saka, inowanikwa kune varwere. Sezvinoita chero tekinoroji nyowani, mutengo unouya nekufamba kwenguva nehunyanzvi hwekuvandudza uye, nepo isu tisingakwanise kupa ruzivo rwakakwana nekuda kwekuvanzika, kwave nezviitiko zvakawanda apo. TECNICMidziyo yemidziyo yakawedzera zvakanyanya kugadzirwa kwemishonga iyi.

Nezvedu zvizere automatic bioreactor eLAB® Advanced uye nekuda kwekumisikidzwa kwayo kwakawanda (kusvika gumi nemaviri ezvikepe zvakazvimirira zvakazara), mumwe wevatengi vedu ari kuita kusimudzira kukuru kwe autologous cell therapy yekutsiva yakakuvadzwa mwongo mushure mekushongedza kenza kurapwa. Kuziva kuti, sekunge chero rudzi rwesero therapy, iyo yekupedzisira-chigadzirwa mhando uye huwandu hunoenderana nehuwandu hwekutanga hweT masero akagadziridzwa uye akawedzera ex vivo, uyu mutengi chaiye aive nezvikuru zviviri zvakakosha zvinodiwa:

  • Nekuda kwekuda kwakashata kwekuenderana, murwere wese T masero akabatidzwa kuti akonzere ex vivo kuwedzera kunodiwa kubva kune yakasarudzika bioreactor tsika.
  • Zvakare, nekuti murwere wavo anowanzo kurwara zvakanyanya, T masero avo anowanzo kura, akasiyaniswa uye anogona kunge akaremedza kukura, saka mutengi wedu aifanira kukwanisa wedzera sero mumamiriro ezvinhu akaoma kwazvo.

Kuti tigutse aya mapoinzi maviri, isu takakurudzira mutengi wedu iyo eLAB® Advanced ⇀. Nekuda kwemidziyo iyi, yakagadzirwa nekusiyana-siyana mupfungwa, bioreactor yedu yakavapa simba rekusimudzira nehupamhi hwepamusoro uye kudzora huwandu hukuru hweakasiyana T cell tsika dzevarwere vavo, zvichivagonesa kugadzirisa tsika yavo mamiriro vachishandisa automatic control unit inodzorwa neindasitiri PLC. Nayo, vakakwanisa kuve nekutonga kwakazara pamusoro peakakosha paramita - senge tembiricha, pH, yakanyungudika okisijeni, uye agitation kumhanya - anosvika gumi nemaviri akazvimirira akazvimirira ega evarwere panguva imwe chete nekuvimbika uye kugona.

Uyu mutengi mumwechete, achiona zvakapfuura zvakanaka mhedzisiro ne TECNIC midziyo uye rubatsiro, akasarudza kuwedzera-up imwe yemaitiro avo ekare ekushanda ane allogenic therapies, ayo akagadzirwa mumabheji makuru kubva kune asina hukama evanopa tishu akadai semwongo wemapfupa. Kuti vaite kuti allogenic cell therapy iwanikwe kune varwere, yavo logistics uye mutengo zvidzidzo zvaida autokugadzirwa kwemamatic mutsika dze50 L.

 

Ongorora huwandu hwedu hwakakwana hwemidziyo

Yedu bioreactors yakagadzirirwa kushandiswa kwakasiyana, kuve nechokwadi chekushanda uye kunaka. Tsvaga yedu yakazara yakazara biotechnology mhinduro, kusanganisira Bioreactors, Tangential Flow Filtration masisitimu, nezvimwe. Shanyira mapeji edu e Bioreactors ⇀, Tangential Flow Sefa ⇀, uye Contact ⇀ kuti uwedzere information uye kubvunza.