15 kusvika Kubvumbi 2024

Kamwechete-kushandisa bioreactors kumushonga wakasarudzika

Kufambira mberi mukurapa kwemunhu ne TECNIC Bioprocess Solutions

The TECNIC-BYOTIC Joint venture yakasarudzwa kuti iite chikamu chekutanga che pre-Commerce yekutenga veruzhinji kuti igadziriswe yehungwaru chikuva che-single-use bioreactors zvakafanana, zvakagadzirirwa kushandiswa mu. autologous cell therapy. Dambudziko renyika yose iri riri kusimudzirwa neve Carlos III Health Institute (ISCIII) uye Center for the Development of Industrial Technology (CDTI) Sarudzo iyi inomiririra kucherechedzwa kwakakosha kwehunyanzvi uye hwehunyanzvi hwekugona kweUTE yedu, pamwe nedanho rakakosha rekusimudzira matekinoroji anobvumira kufambira mberi mumasero ekurapa.

Single-kushandisa bioreactors vane hutsva nekuti vanobvisa kudiwa kwekudzokororwa kucheneswa uye sterilization pakati pemabhechi ekugadzira, izvo zvakakosha mukugadzirwa kwemunhu kurapwa. Ivo zvakare vanoderedza zvakanyanya njodzi yekusvibiswa-muchinjika uye kuwedzera kugona kwemaitiro ekugadzira nekudzikisa kuderera pakati pemabhechi.

Perfusion uye kutonga kwepamusoro mune imwe-kushandisa bioreactors

TECNIC Bioprocess Solutions 'purojekiti yekusimudzira single-use bioreactors inosanganisira advanced perfusion matekinoroji uye akaomesesa ekudzora masisitimu, kiyi yekugonesa kugadzirwa kwebiopharmaceuticals zvichibva pa autologous masero.

Iyo bioreactors yakagadzirwa na TECNIC sanganisira a perfusion maitiro iyo inobvumira kudya kwakanaka uye kubvisa midhiya mukati mesero tsika pasina kukanganisa nharaunda isina kuchena ye reactor. Iyi sisitimu yakakosha pakuchengetedza kushanda kwesero panguva yakareba yetsika. Izvo zvakakoshawo kune autologous cell kugadzirwa uko mhando yechigadzirwa uye kuchena kwakakosha.

Inopfuurira perfusion inobatsira kuchengetedza mamiriro akanaka mukati meiyo bioreactor, kuenzanisa zvinovaka muviri uye kubvisa tsvina yemetabolism inogona kutadzisa kukura kwesero kana kukanganisa kunaka kwechigadzirwa chekupedzisira. Iyi nzira inoitwa kuburikidza nekushandiswa kwepamusoro-inoshanda membrane mafirita anobvumira kusarudza passzera rekudya uye kubviswa kwemarara, kuve nechokwadi chekuti masero anochengetedzwa munzvimbo yakakwana yekuwedzera uye kusiyanisa.

Kudzora uye kuongorora software

Chinhu chitsva cheiyo bioreactor dhizaini kubatanidzwa kwayo nekutonga kwepamberi Software iyo inotarisa uye inoronga zvese zvakakosha zvekurima. Iyi software, yakagadzirirwa zvakanangana neakaomarara bioprocessing mashandiro, inobvumira chaiyo-nguva yekutarisisa ma paramita akadai sepH, tembiricha, okisijeni uye kabhoni dhaimoni mazinga, zvinovaka muviri uye metabolite concentrations, pakati pevamwe.

Iyo yekudzora sisitimu ine intuitive interfaces inogonesa bioreactor manejimendi, ichibvumira vashandisi kugadzirisa mamiriro ekuita nekukurumidza uye nemazvo zvichibva pane chaiyo-nguva data. Izvi zvakakosha kuti uve nechokwadi chekuti nzira yekurima inosangana nemadimikira anodiwa kune yega yega batch yekugadzira.

Uye zvakare, iyo software inosanganisa muchina kudzidza maalgorithms anogona kufanotaura uye kugadzirisa mamiriro ekurima kuti agone kuita bioprocess mhedzisiro. Uku kugona kwekufanotaura hakungonatsiridza kugona uye kushanda kwekugadzirwa kwebiopharmaceutical, asi zvakare kunoderedza njodzi yekukanganisa kwevanhu uye kunowedzera kuberekana kwemabhechi ekugadzira.

Makwikwi mabhenefiti, kudzikisa mutengo, uye kugadzira optimization

Iyo modular uye inochinjika dhizaini yebioreactors inovabvumira kuti vagadziriswe kune akasiyana masikero ekugadzira, kubva madiki mabheji ekutsvagisa kune yakakura-yakakura kugadzira inodiwa kutengeserana kwekurapa. Kuitwa kwekamwe-kushandisa bioreactors kunoratidza zvakare TECNIC's kuzvipira kune inoenderera maitiro, sezvo ivo zvakanyanya kuderedza mvura uye simba consumption inofananidzwa neyechinyakare yakawanda-yekushandisa masisitimu.

Makwikwi mabhenefiti, kuderedzwa kwemutengo uye kugadzirisa kugadzirwa:

  1. Kuderedza kudiwa kwekucheneswa uye sterilization: Single-use bioreactors inobvisa kudiwa kwekudzokorora kuchenesa uye sterilization maitiro pakati pemabhechi, inova yakajairwa muStainless simbi masisitimu. Shanduko iyi inoderedza zvakanyanya kushandiswa kwezviwanikwa zvakaita semvura, simba, uye makemikari ekuchenesa, uye zvakare inoderedza nguva yekudzikira kwemidziyo, zvichibvumira shanduko yekukurumidza pakati pemabhechi ekugadzira. Nekubvisa maitiro aya, TECNIC haingodzikisi kukanganiswa kwezvakatipoteredza asiwo inoderedza mitengo ine chekuita nezvakaiswa uye basa rinodiwa pakugadzirisa michina.

  2. Ngozi yakaderera yekusvibiswa: Kamwechete-kushandisa bioreactors inopa nharaunda isina hutachiona nedhizaini, ichideredza zvakanyanya njodzi yekusvibiswa-muchinjika. Iyi ficha inonyanya kukosha mukugadzirwa kwebiopharmaceutical, uko kusvibiswa kunogona kutungamira mukurasikirwa kwemabhechi ese, zvichikonzera kuwedzera kwemitengo uye kunonoka kugadzira. Kuvandudzwa kwekuchengetedzwa kwechigadzirwa hakungokwidziri mutengo wekushandisa chete asiwo kunodzivirira kutendeseka kwemhando uye kuvimba nevatengi.

  3. Kuwedzera kugadzirwa kuchinjika: Iyo modular dhizaini uye nyore kwekumisikidzwa kweimwe-kushandisa bioreactors inobvumira TECNIC kukurumidza kuchinjika kune akasiyana kugadzirwa zviyero kana chinja pakati pemhando dzakasiyana dzezvigadzirwa pasina imwe yekuwedzera mari yekushandisa. Izvi zvakakosha pakupindura zvine hungwaru kune zvinodiwa pamusika uye pakutsvaga nekuvandudza biopharmaceuticals nyowani. Iko kugona kuyera kugadzirwa pasina kukosha kwakakosha mumidziyo mitsva kunoderedza iyo CAPEX inodiwa pakuwedzera uye kusiyanisa.

  4. Kushanda zvakanaka uye kuderedzwa kweOPEX: Nekubatanidza epamberi ekutarisa uye kutonga masisitimu, TECNIC inowedzera kugadzirwa kwemaitiro. Aya masisitimu anoderedza OPEX nekugadzirisa mashandisirwo ezviwanikwa uye kuvandudza mhando yechigadzirwa chekupedzisira, kuderedza kurasikirwa uye kudiwa kwekudzokororwa kwebatch. Real-time monitoring uye kugadziridzwa kweakakosha paramita kunoitawo kuti maitiro acho awedzere kufanotaura uye asatadze kukanganisa zvinodhura.

  5. Kukwikwidza mumusika wepasi rose: Iko kusanganiswa kwekudzikisa mutengo, kuwedzera kuchinjika kwekugadzira, uye kuvandudzwa kwemhando yechigadzirwa TECNIC semutungamiri anokwikwidza mumusika wepasi rose biopharmaceutical. Aya mabhenefiti anogonesa kambani kupa inodhura-inoshanda uye yakavimbika mhinduro, kukwezva yakafara yevatengi base uye kutevedzera pasi rose mirairo yekugadzira mishonga.

Kudyidzana nerutsigiro rwemasangano

Imwe yebudiriro yakakosha yepurojekiti yakavakirwa pakubatana kwehunyanzvi nemasangano anotungamira mune zvehutano nekutsvaga. Consortium iyi inosanganisira AutoYunivhesiti yeBarcelona, ivo Catalan Ropa uye Tissue Bank, Uye Clinic Hospital yeBarcelona, imwe neimwe inopa hunyanzvi hwakasiyana hwakakosha mukukunda matambudziko ehunyanzvi uye ekiriniki anotarisana nawo chirongwa chedu.

AutoYunivhesiti yeBarcelona (UAB)
Catalan Ropa uye Tissue Bank
Clinic Hospital yeBarcelona
Carlos III Institute

Future impact uye chiono

Kukanganisa kwechirongwa ichi kunodarika kungovandudza kugadzirwa kwemishonga yemunhu. Inoisa mwero mutsva wezvitsva zveramangwana mumunda webiotechnology, wakanangana nekurapa kusiri kwemunhu chete, asi zvakare kunogadzirwa zvakanyanya uye zvakachengeteka. Nechirongwa ichi TECNIC iri kutungamira nzira yeramangwana umo mushonga wakasarudzika usiri sarudzo chete, asi chokwadi chinoshanda uye chinowanikwa kune vese, zvichifambiswa neshanduko yebudiriro yebioprocess tekinoroji.

Iyi purojekiti inoratidza kuzvipira kuenderera mberi nekuvandudza uye nehunyanzvi hutsva. Iyo kambani iri kutanga mapuratifomu matsva ekugadzira autologous cell-based biopharmaceuticals, inomiririra yakasarudzika nzira yemushonga wakasarudzika inoda kunangana sero kubatwa nemurwere. Izvi hazvingogadzirisi nzira dzekurapa chete, asiwo zvinosimudza zviyero zvemhando uye chengetedzo mukugadzirwa kwekurapa.

Pamusoro pezvo, chirongwa ichi chinosimudzira kubatanidza matekinoroji epamusoro senge-single-use bioreactors, ayo akakosha pakuitwa kwakanaka kwemaitiro akaomarara ebiotechnological. Zviitiko izvi zvakagadzirirwa kuderedza zvakanyanya mutengo uye nguva dzekugadzira, zvichiita kuti kurapwa kwepamusoro kuwanikwe uye kuwedzere. Nekushandisa budiriro idzi, TECNIC haisi kungovandudza hunhu hwekurapa kwekurapa, asi zvakare kutyaira nguva nyowani yekuwanikwa mukurapa kwemunhu.

Pakupedzisira, TECNIC iri kubatsira mukusimudzira hupfumi uye tekinoroji nekukurudzira kusikwa kweruzivo uye kuendesa tekinoroji pakati pezvidzidzo neindasitiri. Iyi nzira yekudyidzana inoita kuti hutsva hwakagadzirwa mulabhu husvike pamusika, kushandura tsvakiridzo yepamusoro kuita mhinduro dzinobatika dzinobatsira nzanga yese.

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Midziyo yedu, kuenderana nayo Cassette mafirita, inopa hukuru hwekusiyana-siyana uye kuchinjika. Izvi zvinoreva kuti iwe unogona kusarudza sefa inonyatso kuenderana nezvido zvako, kuve nechokwadi chekuti kuyedza kwega kwega kana maitiro ekugadzira anoitwa nekunyatsogona uye nemazvo.

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