Chii chinonzi TFF system uye inoshanda sei?

Muchikamu chino, tichatsanangura zvakadzama kuti TFF system (Tangential Flow Filtration) chii uye kuti inoshandiswa chii, ichipa muchidimbu mashandisirwo ayo, zvakanakira, matambudziko uye ramangwana.

Nhanganyaya kune TFF masisitimu

Tangential Flow Filtration inzira yepamusoro inoshandiswa kuparadzanisa uye kuchenesa biomolecules, senge mapuroteni, maseru uye zvimwe zvipenyu zvinoumba. Kusiyana zvakananga filtration, apo kuyerera passes perpendicularly kuburikidza nesefa, muTFF kuyerera passs tangentially kune membrane pamusoro. Iyi nzira inobvumira zvimwe inobudirira filtration process, kuderedza kuumbwa kwechikamu pa membrane uye kurebesa hupenyu hwayo.

Iyo TFF sisitimu inonyanya kubatsira mumashandisirwo uko kwakakosha kuchengetedza kutendeseka kwebiomolecules uye uko kwakanyanya kupatsanurwa kwakanaka kunodiwa. Inoshandiswa mumarabhoritari ekutsvagisa uye kugadzirwa kwemaindasitiri.

Nhoroondo uye shanduko yeTFF

Tangential flow filtration yakatanga kugadzirwa muma1970 nema1980, kunyanya yekuchenesa mapuroteni uye kupatsanurwa kwesero mumarabhoritari ekutsvagisa. Kubva ipapo, TFF yakashanduka zvakanyanya uye yakabatanidzwa mumaitiro makuru ekugadzira.

Pakutanga, mamembrane aishandiswa muTFF aive asina kunyatso shanda uye aiwanzoita foiling. Nekudaro, nekufambira mberi mune zvesainzi uye membrane engineering, akasimba uye anoshanda membrane akagadzirwa. Kufambira mberi uku kwakagonesa masisitimu eTFF kuti ave chishandiso chakakosha chekucheneswa uye kuunganidzwa kwezvigadzirwa zvebhayoloji, zvichibatsira mukugadzirwa kwakawanda kwemishonga yebiology nezvimwe zvigadzirwa zvebiotechnology.

Mhando dzeTFF Systems

Mhando dzinoverengeka dzeTFF masisitimu akagadzirirwa akasiyana maapplication uye zvinodiwa

Hollow fiber
Cassette
zvedongo
Flat module
Spiral cartridge

TFF system inoshanda sei?

Mune TFF system, mhinduro inopombwa tangentially pamusoro pesefa membrane. Uku kuyerera kwetangential kunochengeta zvimedu zvichifamba, zvichideredza kuvaka-pamusoro pe membrane uye nekuvandudza kusefa kushanda zvakanaka. Nzira yacho inogona kuva suminogadziriswa mumatanho anotevera:

  1. Kugadziriswa kwekugadziriswa: Mhinduro ine biomolecules kana zvimedu zvinopatsanurwa inogadzirwa uye inoiswa muTFF system.
  2. Kupomba uye kusefa: Mhinduro yacho inoputirwa kuburikidza ne membrane module, apo tangential inoyerera inochengetedza zvikamu mukufamba uye inodzivirira kuvhara kwe membrane.
  3. Permeate uye chengetedza muunganidzwa: Iyo filtrate (permeate) inounganidzwa mumudziyo wepermeate, nepo zvikamu zvakaparadzana (retainer) zvinounganidzwa mumudziyo wekuchengetedza kuti uwedzere kugadziriswa kana kuraswa.

Zvishandiso zveTFF masisitimu

  1. Pharmaceutical industry: kucheneswa uye kusangana kwemapuroteni, masoja ekudzivirira chirwere uye zvimwe zvipenyu zvigadzirwa. TFF yakakosha mukugadzirwa kwemishonga yebiological, senge majekiseni uye monoclonal therapies, kuve nechokwadi chekuchena kwakaringana uye kusungirirwa kwezvigadzirwa zvekupedzisira.
  2. hwokushandura zvinhu zvipenyu: Kuparadzaniswa uye kucheneswa kwemasero, mavhairasi uye zvimwe zvipenyu zvikamu. Mutsvagiridzo yebiotechnological, TFF inoshandiswa kugadzirira yakachena uye yakamisikidzwa biological samples yezvidzidzo zvakasiyana uye mashandisirwo.
  3. Food industry: Kuiswa kwemajusi, zvigadzirwa zvemukaka uye zvimwe zvinwiwa zvekudya. Flow filtrations masisitimu anobatsira kuvandudza kunaka uye kugadzikana kwezvigadzirwa zvekudya nekubvisa tsvina uye kuisa pfungwa pazvinhu zvinodiwa.
  4. Kurapa kwemvura: Kujekeswa uye kucheneswa kwemvura yakasviba nemvura yekunwa. TFF inoshandiswa kubvisa zvinosvibisa uye zvimedu zvisingadiwe kubva mumvura, kuvandudza kunaka kwayo uye kuita kuti ive yakakodzera kushandiswa zvakare kana kukanganisa.sumption.

Mhando dzeKusefa

Mukati memunda wekusefa tekinoroji, kune akati wandei marudzi anoshandiswa zvichienderana nehukuru hwezvimedu zvinopatsanurwa uye chaiyo application:

Microfiltration
Ultrafiltration
Nanofiltration

mhedziso

In summary, tangential flow filtration (TFF) inyanzvi yepamberi inogonesa kushanda zvakanaka kupatsanurwa nekucheneswa yebiomolecules uye zvimedu. Nekuda kwekugadzirwa kwayo uye kushanda kwayo, kusefa kwemuchinjiko kwave chishandiso chakakosha mune zvemazuva ano biotechnology uye maindasitiri akasiyana. Iko kugona kuchengetedza inoenderera uye inodzorwa kuyerera, pamwe chete nenjodzi yakadzikira yekuvharika, inoita kuti TFF masisitimu ive sarudzo inosarudzika kune akawanda maindasitiri ekushandisa.

Kana iwe uchifarira nyika yebiotechnology, udza mashoko TECNIC chikwata kune mazano uye rubatsiro pakusarudza kubva yedu yakakura yemidziyo yeTFF, ine nzvimbo dzekusefa kubva pa0.1m² kusvika 36.3m²

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Inoratidzwa neayo radial blades akaiswa perpendicularly kune shaft, iyo Rushton impeller inogadzirwa kuti ipe yakakwirira shear mazinga uye yakanakisa gasi kupararira, iyo inonyanya kushanda mumicrobial. Mune biotechnological application inosanganisira mabhakitiriya uye mbiriso, iyo Rushton impeller inokunda nekuita kuti homogeneous kusanganiswa uye kugovera gasi kwakaringana, kunyangwe mutsika dzakasimba.

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Cassette

Isu tinonzwisisa kukosha kwekushanduka uye kushanda zvakanaka mumarabhoritari maitiro. Ndicho chikonzero midziyo yedu yakagadzirirwa kuti ienderane nayo Cassette Filters, mhinduro yepamusoro yezvakasiyana-siyana zvefiltration application. Kunyangwe isu tisingagadziri mafirita zvakananga, masisitimu edu anogadziridzwa kuti atore mukana wakazara wemabhenefiti ayo Cassette mafirita anopa.

Cassette mafirita anozivikanwa nekukwira kwawo kwesefa uye kugona mukuparadzanisa, achiaita akanakira Ultrafiltration, microfiltration, uye nanofiltration application. Nekubatanidza mafirita aya mumidziyo yedu, tinofambisa maitiro anokurumidza uye anoshanda, tichiona mhedzisiro yemhando yepamusoro.

Midziyo yedu, kuenderana nayo Cassette mafirita, inopa hukuru hwekusiyana-siyana uye kuchinjika. Izvi zvinoreva kuti iwe unogona kusarudza sefa inonyatso kuenderana nezvido zvako, kuve nechokwadi chekuti kuyedza kwega kwega kana maitiro ekugadzira anoitwa nekunyatsogona uye nemazvo.

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Hollow Fiber

Isu tinocherekedza basa rakakosha rekuchinjika uye kugona mumarabhoritari maitiro. Ndicho chikonzero midziyo yedu yakagadzirwa zvine hungwaru kuti ienderane nayo Hollow Fiber Filters, ichipa mhinduro yepamusoro kune yakafara spectrum yekusefa maapplication. Kunyange isu tisingagadziri masefa aya zvakanangana, masisitimu edu akakwenenzverwa kuti ashandise kugona kwakazara kwe Hollow Fiber filters.

Hollow Fiber mafirita anozivikanwa nekuita kwawo kwakasarudzika maererano nekusefa kwakanaka uye kugona. Iwo anonyanya kushanda kune maapplication anoda kubatwa zvinyoro nyoro kwemasamples, senge musero tsika uye sensitive biomolecular process. Nekubatanidza mafirita aya nemidziyo yedu, tinogonesa kuita kwakawanda, nekukurumidza, uye kwemhando yepamusoro kusefa maitiro.

Chii chinosiyanisa midziyo yedu ndeye 100% automation kugona. Kuburikidza nekushandiswa kweakaomesesa proportional mavharuvhu, masisitimu edu anowana kudzora zvine hungwaru kusiyana kwekumanikidzwa, transmembrane pressure, uye kuyerera kwehuwandu. Level iyi ye automation haingokwidzi kushanda uye iko kurongeka kwesefa asi zvakare inoderedza zvakanyanya kukosha kwekutarisa nemanyorero, ichipa masisitimu edu akavimbika uye ane hushamwari mushandisi.

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