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We understand the importance of flexibility and efficiency in laboratory processes. That's why our equipment is designed to be compatible with Cassette filters, an advanced solution for a variety of filtration applications. Although we do not manufacture the filters directly, our systems are optimized to take full advantage of the benefits that Cassette filters offer.
Cassette filters are known for their high filtration capacity and efficiency in separation, making them ideal for ultrafiltration, microfiltration, and nanofiltration applications. By integrating these filters into our equipment, we facilitate faster and more effective processes, ensuring high-quality results.
Our equipment, being compatible with Cassette filters, offers greater versatility and adaptability. This means you can choose the filter that best suits your specific needs, ensuring that each experiment or production process is carried out with maximum efficiency and precision.
Moreover, our equipment stands out for its 100% automation capabilities. Utilizing advanced proportional valves, we ensure precise control over differential pressure, transmembrane pressure, and flow rate. This automation not only enhances the efficiency and accuracy of the filtration process but also significantly reduces manual intervention, making our systems highly reliable and user-friendly.
We recognize the crucial role of flexibility and efficiency in laboratory processes. That's why our equipment is meticulously designed to be compatible with Hollow Fiber filters, providing an advanced solution for a broad spectrum of filtration applications. While we don't directly manufacture these filters, our systems are finely tuned to harness the full potential of Hollow Fiber filters.
Hollow Fiber filters are renowned for their exceptional performance in terms of filtration efficiency and capacity. They are particularly effective for applications requiring gentle handling of samples, such as in cell culture and sensitive biomolecular processes. By integrating these filters with our equipment, we enable more efficient, faster, and higher-quality filtration processes.
What sets our equipment apart is its 100% automation capability. Through the use of sophisticated proportional valves, our systems achieve meticulous control over differential pressure, transmembrane pressure, and flow rate. This level of automation not only boosts the efficiency and precision of the filtration process but also significantly diminishes the need for manual oversight, rendering our systems exceptionally reliable and user-friendly.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The microbial configuration of the eLab Advanced is equipped with a Rushton turbine specifically designed for high-oxygen-demand processes such as bacterial and yeast fermentations. The radial-flow impeller generates strong mixing and intense gas dispersion, promoting high oxygen transfer rates and fast homogenization of nutrients, antifoam and pH control agents throughout the vessel. This makes it particularly suitable for robust microbial strains operating at elevated agitation speeds and aeration rates.
Operators can adjust agitation and gas flow to reach the required kLa while maintaining consistent mixing times, even at high cell densities. This configuration is an excellent option for users who need a powerful, reliable platform to develop and optimize microbial processes before transferring them to pilot or production scales.
Seals/elastomers: platinum-cured silicone, EPDM and/or PTFE (material set depends on selection)
Elastomers compliance (depending on selected materials): FDA 21 CFR 177.2600 and USP Class VI
Surface treatments: degreasing, pickling and passivation (ASTM A380 and ASTM A968)
Roughness control on product-contact surfaces
Design conditions
Pressure & temperature
Defined considering non-hazardous process fluids (PED group 2) and jacket steam/superheated water (PED group 5), depending on configuration and project scope.
Reference design envelope
Mode
Element
Working pressure (bar[g])
Working pressure (psi[g])
T max (°C / °F)
Process
Vessel
0 / +2.5
0 / +36.3
+90 / 194
Process
Jacket
0 / +3.8
0 / +55.1
+90 / 194
Sterilisation
Vessel
0 / +2.5
0 / +36.3
+130 / 266
Sterilisation
Jacket
0 / +3.8
0 / +55.1
+150 / 302
Jacket working pressure may also be specified as 0 / +4 bar(g) (0 / +58.0 psi[g]) depending on design selection; final values are confirmed per project.
Pressure control and safeguards
Typical
Designed to maintain a vessel pressure set-point typically in the range 0 to 2.5 bar(g)
Aseptic operation commonly around 0.2 to 0.5 bar(g) to keep the vessel slightly pressurised
Overpressure/underpressure safeguards included per configuration and regulations
Pressure safety device (e.g., rupture disc and/or safety valve) included according to configuration
Agitation
Reference ranges
Working volume
MU (Cell culture), reference
MB (Microbial), reference
10 L
0 to 300 rpm
0 to 1000 rpm
20 L
0 to 250 rpm
0 to 1000 rpm
30 L
0 to 200 rpm
0 to 1000 rpm
50 L
0 to 180 rpm
0 to 1000 rpm
Integrated peristaltic pumps (additions)
Typical
The equipment typically includes 4 integrated variable-speed peristaltic pumps for sterile additions (acid/base/antifoam/feeds). Actual flow depends on selected tubing and calibration.
Parameter
Typical value
Notes
Quantity
4 units (integrated)
In control tower; assignment defined by configuration
Speed
0-300 rpm
Variable control from eSCADA
Minimum flow
0-10 mL/min
Example with 0.8 mm ID tubing; depends on tubing and calibration
Maximum flow
Up to ~366 mL/min
Example with 4.8 mm ID tubing; actual flow depends on calibration
Operating modes
OFF / AUTO / MANUAL / PROFILE
AUTO typically associated to pH/DO/foam loops or recipe
Functions
PURGE, calibration, totaliser, PWM
PWM available for low flow setpoints below minimum operating level
Gas flow control (microbial reference capacity)
Reference
For microbial culture (MB), gas flow controllers (MFC) are typically sized based on VVM targets. Typical reference VVM range: 0.5-1.5 (to be confirmed by process).
Working volume (L)
VVM min
VVM max
Air (L/min)
O2 (10%) (L/min)
CO2 (20%) (L/min)
N2 (10%) (L/min)
10
0.5
1.5
5-15
0.5-1.5
1-3
0.5-1.5
20
0.5
1.5
10-30
1-3
2-6
1-3
30
0.5
1.5
15-45
1.5-4.5
3-9
1.5-4.5
50
0.5
1.5
25-75
2.5-7.5
5-15
2.5-7.5
O2/CO2/N2 values are shown as reference capacities for typical gas blending strategies (10% O2, 20% CO2, 10% N2). Final gas list and ranges depend on process and configuration.
Instrumentation and sensors
Typical
Instrumentation is configurable. The following list describes typical sensors integrated in standard configurations, plus common optional PAT sensors.
Variable / function
Typical technology / interface
Status (STD/OPT)
Temperature (process/jacket)
Pt100 class A RTD
STD
Pressure (vessel/lines)
Pressure transmitter (4-20 mA / digital)
STD
Level (working volume)
Adjustable probe
STD
pH
Digital pH sensor (ARC or equivalent)
STD
DO (pO2)
Digital optical DO sensor (ARC or equivalent)
STD
Foam
Conductive/capacitive foam sensor
STD
Weight / mass balance
Load cell (integrated in skid)
STD
pCO2
Digital pCO2 sensor (ARC or equivalent)
OPT
Biomass (permittivity)
In-line or in-vessel sensor
OPT
VCD / TCD
In-situ cell density sensors
OPT (MU)
Off-gas (O2/CO2)
Gas analyser for OUR/CER
OPT
ORP / Redox
Digital ORP
OPT
Glucose / Lactate
PAT sensor
OPT
Automation, software and connectivity
Typical
The platform incorporates TECNIC eSCADA (typically eSCADA Advanced for ePILOT) to operate actuators and control loops, execute recipes and manage process data.
Main software functions
Main overview screen with process parameters and trends
Alarm management (real-time alarms and historical log) with acknowledgement and comment option
Manual/automatic modes for actuators and control loops
Recipe management with phases and transitions; parameter profiles (multi-step) for pumps and setpoints
Data logging with configurable period and export to CSV; PDF report generation
Common control loops
Temperature control (jacket heating/cooling)
Pressure control (headspace) with associated valve management
pH control via acid/base addition pumps and optional CO2 strategy
DO control with cascade strategies (agitation, air, O2, N2) depending on package and configuration
Foam control (foam sensor and automatic antifoam addition)
Data integrity and 21 CFR Part 11
Support for 21 CFR Part 11 / EU GMP Annex 11 is configuration- and project-dependent and requires customer procedures and validation (CSV).
Utilities
Reference
Utilities depend on final configuration (e.g., AutoSIP vs External SIP) and destination market (EU vs North America). The following values are typical reference points.
Utility
Typical service / configuration
Pressure
Flow / power
Notes
Electrical
EU base: 400 VAC / 50 Hz (3~)
N/A
AutoSIP: 12 kW; External SIP: 5 kW
NA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required
Process gases
Air / O2 / CO2 / N2
Up to 2.5 bar(g) (36.3 psi)
According to setpoint
Typical OD10 pneumatic connections; final list depends on package
Instrument air
Pneumatic valves
Up to 6 bar(g) (87.0 psi)
N/A
Dry/filtered air recommended
Cooling water
Jacket cooling water
2 bar(g) (29.0 psi)
25 L/min (6.6 gpm)
6-10 °C (43-50 °F) typical
Cooling water
Condenser cooling water
2 bar(g) (29.0 psi)
1 L/min (0.26 gpm)
6-10 °C (43-50 °F) typical
Steam (External SIP)
Industrial steam
2-3 bar(g) (29.0-43.5 psi)
30 kg/h (66 lb/h)
For SIP sequences
Steam (External SIP)
Clean steam
1.5 bar(g) (21.8 psi)
8 kg/h (18 lb/h)
Depending on plant strategy
Compliance and deliverables
Typical
Depending on destination and project scope, the regulatory basis may include European Directives (CE) and/or North American codes. The exact list is confirmed per project and stated in the Declaration(s) of Conformity when applicable.
NEC/NFPA 70; UL/CSA components and marking as required
Materials contact
EC 1935/2004 + EC 2023/2006 (GMP for materials) where applicable
FDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance
Software / CSV
EU GMP Annex 11 (if applicable)
21 CFR Part 11 (if applicable)
Standard documentation package
User manual and basic operating instructions
P&ID / layout drawings as per project scope
Material certificates and finish/treatment certificates (scope dependent)
FAT report (if included in contract)
Optional qualification and commissioning services
SAT (Site Acceptance Test)
IQ / OQ documentation and/or execution (scope agreed with customer)
CSV support package for regulated environments (ALCOA+ considerations, backups, time synchronisation, etc.)
Ordering and configuration
Project-based
ePILOT BR is configured per project. To define the right MU/MB package, volumes and options (utilities, sensors, software and compliance), please contact TECNIC with your URS or request the configuration questionnaire.
The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The ePlus Mixer platform combines an ePlus Mixer control tower with Tank frames and eBag 3D consumables.
Tank can be supplied in square or cylindrical configurations (depending on project) to match the bag format.
Tank model
Nominal volume
Minimum volume to start agitation*
Tank 50 L
50 L
15 L
Tank 100 L
100 L
20 L
Tank 200 L
200 L
30 L
Tank 500 L
500 L
55 L
*Values based on agitation start interlocks per tank model. Final performance depends on the selected eBag 3D, fluid properties and configuration.
Design conditions and operating limits
Reference
Reference limits are defined for the ePlus Mixer and the Tank. It is recommended to validate
the specific limits of the selected eBag 3D and single-use sensors for the customer’s process.
Element
Operating pressure
Maximum pressure (safety)
Maximum working temperature
ePlus Mixer (control tower)
ATM
0.5 bar(g)
90 °C
Tank
ATM
0.5 bar(g)
45 °C
Jacket (if applicable)
N/A
1.5 bar
Depends on utilities / scope
The 0.5 bar(g) limit is associated with the equipment design, the circuit is protected by a safety valve.
Confirm final limits on the equipment nameplate and project specification.
Materials and finishes
Typical
Control tower housing and frame: stainless steel 304
Product-contact metallic hard parts (if applicable): stainless steel 316 (defined in project manufacturing documentation)
Vent filters: PP (polypropylene), per component list
For GMP projects, the recommended documentation package includes material certificates, surface finish certificates (Ra if applicable) and consumable sterility/irradiation certificates.
Agitation system
Magnetic
Non-invasive magnetic agitation, the impeller is integrated in the eBag 3D Mixer format, avoiding mechanical seals.
Agitation speed is controlled from the HMI, with start interlocks linked to the tank model and minimum volume.
Reference speed range
Typical agitation range: 120 to 300 rpm (configuration dependent)
Magnetic drive motor (reference): Sterimixer SMA 85/140, 50 Hz, 230/400 V, 0.18 kW
Gear reduction (reference): 1:5
Actuation (reference): linear actuator LEYG25MA, stroke 30–300 mm, speed 18–500 mm/s (for positioning)
Final rpm and mixing performance depend on tank size, bag format and process requirements.
Weighing and volume control
Integrated
Weight and derived volume control are performed using 4 load cells integrated in the tank frame legs and a weight indicator.
Tare functions are managed from the HMI to support preparation steps and additions by mass.
Component
Reference model
Key parameters
Load cells (x4)
Mettler Toledo SWB505 (stainless steel)
550 kg each, output 2 mV/V, IP66
Weight indicator
Mettler Toledo IND360 DIN
Acquisition and HMI display, tare and “clear last tare”
For installation engineering, total floor load should consider product mass + equipment mass + margin (recommended ≥ 20%).
Pumps and fluid handling
Standard
The platform includes integrated pumps for additions and circulation. Final tubing selection and calibration define the usable flow range.
Included pumps (reference)
3 integrated peristaltic pumps for additions (acid/base/media), with speed control from HMI
1 integrated centrifugal pump for circulation / transfer (DN25)
Peristaltic pumps (reference)
Parameter
Reference
Notes
Quantity
3 units
Integrated in the control tower
Pump head
HYB101 (Hygiaflex)
Example tubing: ID 4.8 mm, wall 1.6 mm
Max speed
300 rpm
Speed control reference: 0–5 V
Max flow (example)
365.69 mL/min
Depends on tubing and calibration
Centrifugal pump (reference)
Parameter
Reference
Model
EBARA MR S DN25
Power
0.75 kW
Flow
Up to 42 L/min
Pressure
Up to 1 bar
For circulation and sensor loops, the eBag 3D format can include dedicated ports (depending on the selected consumable and application).
Thermal management (optional jacket)
Optional
Tank can be supplied with a jacket (single or double jacket options). The thermal circuit includes control elements and a heat exchanger,
enabling temperature conditioning depending on utilities and project scope.
Solenoid valves (reference): SMC VXZ262LGK, 1", DC 24 V, 10.5 W
Jacket sequences: fill / empty / flush (scope dependent)
The tank maximum temperature may depend on the thermal circuit and consumable limits. Confirm final values with the selected eBag 3D specification.
Instrumentation and sensors
Optional SU
Single-use sensors can be integrated via dedicated modules. The following references describe typical sensors and interfaces listed in the datasheet.
Variable
Reference model
Interface / protocol
Supply
Operating temperature
IP
pH
OneFerm Arc pH VP 70 NTC (SU)
Arc Module SU pH, Modbus RTU
7–30 VDC
5–50 °C
IP67
Conductivity
Conducell-P SU (SU)
Arc Module Cond-P SU, Modbus RTU
7–30 VDC
0–60 °C
IP64
Temperature
Pt100 ø4 × 52 mm, M8 (non-invasive)
Analog / acquisition module
Project dependent
Project dependent
Project dependent
Measurement ranges and final sensor list depend on the selected single-use components and project scope.
Automation, software and data
Standard + options
The ePlus SUM control tower integrates an industrial PLC and touch HMI. Standard operation supports Manual / Automatic / Profile modes,
with optional recipe execution depending on selected software scope.
Software scope (reference)
Standard: eBASIC (base HMI functions)
Optional: eSCADA Basic or eSCADA Advanced (project dependent)
Trends, alarms and profiles, profiles up to 100 steps (depending on scope)
Data retention (reference): up to 1 year
Connectivity (reference)
Industrial Ethernet and integrated OPC server (included)
Remote access option (project dependent)
Utilities and facility interfaces
Typical
Installation requirements depend on jacket and temperature scope and the customer layout. The following values are typical references.
Utility
Pressure
Flow
Connections
Notes
Electrical supply
N/A
Reference: 18 A
380–400 VAC, 3~ + N, 50 Hz
Confirm per final configuration and destination market
Ethernet
N/A
N/A
RJ45
OPC server, LAN integration
Tap water
2.5 bar
N/A
1/2" (hose connection)
Jacket fill and services, tank volume about 25 L
Cooling water
2–4 bar
10–20 L/min
2 × 3/4" (hose connection)
Heat exchanger and jacket cooling
Process air
2–4 bar
N/A
1/2" quick coupling
Used for jacket emptying
Drain
N/A
N/A
2 × 3/4" (hose connection)
For draining
Exhaust
N/A
N/A
N/A
Optional (depending on project)
Stack light (optional)
N/A
N/A
N/A
3-colour indication, as per scope
During FAT, verify in the installation checklist that the available utilities match the selected configuration and scope.
Documentation and deliverables
Project-based
Deliverables depend on scope and project requirements. The following items are typical references included in the technical documentation package.
Datasheet and user manual (HMI and system operation)
Electrical schematics, PLC program and backup package (scope dependent)
P&ID, layout and GA drawings (PDF and/or CAD formats, project dependent)
Factory Acceptance Test (FAT) protocol and FAT report (as per contract)
Installation checklist
Material and consumable certificates, as required for regulated projects (scope dependent)
On-site services (SAT, IQ/OQ) and extended compliance packages are optional and defined per project.
Ordering and configuration
Contact
The ePlus Mixer scope is defined per project. To select the right tank size, bag format, sensors and optional jacket and software,
please share your URS or request the configuration questionnaire.
The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.
The operating range depends on the volume, gas configuration and impeller type. Typical performance references and operating parameters for both applications are summarised below (guideline values; final performance depends on medium, antifoam, geometry and aeration strategy).
Performance and parameters:
Indicative operating windows for cellular and microbial processes. Final values depend on bag configuration, impellers, aeration strategy and process targets.
Application
Cell culture
Agitation (rpm)
300: 0–450 1000: 0–300
Tip speed (m/s)
0.4–1.8
P/V (W/m³)
80–200
kLa (h⁻¹)
20–30
Application
Microbial
Agitation (rpm)
300: 0–450 1000: 0–300
Tip speed (m/s)
1.5–5.0
P/V (W/m³)
1,000–5,500
kLa (h⁻¹)
150–330
Typical gas line ranges by model and application. Installed ranges and gas setup depend on selected options and project scope.
Gas
Process air
Typical range (Ln/min)
300 L: 20–300 (up to 600 depending on configuration) 1000 L: 20–1000 (up to 2000 depending on configuration)
Main use
Aeration by sparger / mixing
Notes by application
Microbial: primary.
Cellular: DO support.
Gas
Oxygen (O₂)
Typical range (Ln/min)
300 L: 2–30 (up to 600 depending on configuration) 1000 L: 2–100 (up to 2000 depending on configuration)
Main use
DO enrichment and cascade
Notes by application
Microbial: frequent. Cellular: cascade at DO set point.
Gas
Carbon dioxide (CO₂)
Typical range (Ln/min)
300 L: 2–30 (typical) / 10–150 (depending on configuration) 1000 L: 2–100 (typical) / 10–500 (depending on configuration)
Main use
pH control / CO₂ balance
Notes by application
Cellular: standard. Microbial: optional.
Gas
Overlay (air or O₂)
Typical range (Ln/min)
300 L: 10–150 1000 L: 10–500
Main use
Headspace scavenging / gas control
Notes by application
Cellular: standard. Microbial: optional.
Note: the exact flow and gas ranges installed depend on the model and the options purchased.
