Tangential flow filtration for lab, pilot and production

Tangential flow filtration (TFF) is a core step in downstream processing for clarification, concentration and diafiltration. TECNIC provides TFF platforms across scales so you can keep the same operating logic as you move from development to pilot and production, with consistent control of key variables like tangential flow, TMP and ΔP.

Choose the membrane format that fits your process, including cassette and hollow fiber options, and run the workflows you need (concentration, diafiltration, leak test and water flux test). Automation and data management are built in through the HMI/SCADA, with recipe execution, trends, alarms, reports and optional CIP/SIP depending on the configuration.

Multi Use Tangential Flow Filtration Systems

Single Use Tangential Flow Filtration Systems

eLab TFF SU

Laboratoy Scale - Up to 0.7 m²

TFF platforms built around 4 core pillars

Explore our TFF systems by scale, membrane format, application and control to reach the right configuration faster.

Multi Use TFF Systems

eLab TFF

Up to 0.5 m²

Hollow fiber, Cassette, Ceramic membranes

Discover the eLAB TFF, an automatic tangential flow filtration system up to 0.5 m², with 5 or 10 L vessel, cassette or hollow fiber, integrated PLC/SCADA control.

Discover the eLab TFF

ePilot TFF

Up to 6.5 m²

Hollow fiber, Cassette, Ceramic membrane

Discover the ePILOT TFF, a pilot-scale tangential flow filtration system designed for scalable downstream concentration and diafiltration with cassette or hollow fiber configurations.

Discover the ePilot TFF

eProd TFF

Up to 65 m²

Hollow fiber, Cassette, Ceramic membrane

Discover the ePROD TFF, a fully automated tangential flow filtration system up to 65 m², compatible with cassette, hollow fiber or ceramic membranes, for continuous downstream operation.

Discover the eProd TFF

Single Use TFF Systems

eLab TFF SU

Up to 0.7 m²

Discover the eLab TFF Single-Use configuration, a lab-scale tangential flow filtration system designed for reliable process development.

Discover the eLab TFF SU

Download SUB Performance Report ⇀

Single-use consumables for TFF

You’ve seen our single-use TFF platforms, now explore the consumables that complete the workflow. Our single-use TFF bag and flow kit range is manufactured in our in-house ISO 7 cleanroom under aseptic conditions and supplied ready-to-use after gamma irradiation. Each configuration can be defined by volume and fittings, with multiple port layouts plus common connector and tubing options to integrate cleanly into your setup.

For TFF operations, the kits are designed to support typical steps such as flushing, concentration and diafiltration, with consistent connections for feed, retentate and permeate lines. The goal is a faster, cleaner setup and repeatable runs without cleaning between batches.

Single-use consumables for bioreactors and mixing

You’ve seen our single-use bioreactor platforms, now explore the consumables that complete the workflow. The eBag range includes 2D and 3D single-use bags and single-use vessels, manufactured in our in-house ISO 7 cleanroom under aseptic conditions and supplied ready-to-use after gamma irradiation. Configurations can be adapted by volume and fittings, with multiple port layouts and common connector and tubing options to integrate smoothly into your setup.

For mixing applications, eBAG 3D Mixer bags are designed to fit tanks and work with the fully magnetic ePlus Mixer SU, supporting efficient, repeatable liquid handling without cleaning between batches.

Single-use bags for Tangential Flow Filtration Systems

eBag 2D Storage

From 2 to 50 L

Cellular or Microbial

Discover the eBAG 2D Storage, a gamma-irradiated ready-to-use bioprocess bag, ISO 7 cleanroom-made, available in 2, 5, 10, 20 and 50 L, with configurable ports.

Discover the eBag 2D Storage

eBag 2D TFF

From 2 to 50 L

Ready to run on the eLab TFF SU

Discover the eBAG 2D TFF, a gamma-irradiated bag that integrates securely with TECNIC single-use TFF systems via a dedicated Flow Kit and Boat Port, range 2 to 50 L.

Discover the eBag 2D TFF

Consult Our Sales team

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Mode	Element	Working pressure (bar[g])	Working pressure (psi[g])	T max (°C / °F)
Process	Vessel	0 / +2.5	0 / +36.3	+90 / 194
Process	Jacket	0 / +3.8	0 / +55.1	+90 / 194
Sterilisation	Vessel	0 / +2.5	0 / +36.3	+130 / 266
Sterilisation	Jacket	0 / +3.8	0 / +55.1	+150 / 302

Working volume	MU (Cell culture), reference	MB (Microbial), reference
10 L	0 to 300 rpm	0 to 1000 rpm
20 L	0 to 250 rpm	0 to 1000 rpm
30 L	0 to 200 rpm	0 to 1000 rpm
50 L	0 to 180 rpm	0 to 1000 rpm

Parameter	Typical value	Notes
Quantity	4 units (integrated)	In control tower; assignment defined by configuration
Speed	0-300 rpm	Variable control from eSCADA
Minimum flow	0-10 mL/min	Example with 0.8 mm ID tubing; depends on tubing and calibration
Maximum flow	Up to ~366 mL/min	Example with 4.8 mm ID tubing; actual flow depends on calibration
Operating modes	OFF / AUTO / MANUAL / PROFILE	AUTO typically associated to pH/DO/foam loops or recipe
Functions	PURGE, calibration, totaliser, PWM	PWM available for low flow setpoints below minimum operating level

Working volume (L)	VVM min	VVM max	Air (L/min)	O2 (10%) (L/min)	CO2 (20%) (L/min)	N2 (10%) (L/min)
10	0.5	1.5	5-15	0.5-1.5	1-3	0.5-1.5
20	0.5	1.5	10-30	1-3	2-6	1-3
30	0.5	1.5	15-45	1.5-4.5	3-9	1.5-4.5
50	0.5	1.5	25-75	2.5-7.5	5-15	2.5-7.5

Variable / function	Typical technology / interface	Status (STD/OPT)
Temperature (process/jacket)	Pt100 class A RTD	STD
Pressure (vessel/lines)	Pressure transmitter (4-20 mA / digital)	STD
Level (working volume)	Adjustable probe	STD
pH	Digital pH sensor (ARC or equivalent)	STD
DO (pO2)	Digital optical DO sensor (ARC or equivalent)	STD
Foam	Conductive/capacitive foam sensor	STD
Weight / mass balance	Load cell (integrated in skid)	STD
pCO2	Digital pCO2 sensor (ARC or equivalent)	OPT
Biomass (permittivity)	In-line or in-vessel sensor	OPT
VCD / TCD	In-situ cell density sensors	OPT (MU)
Off-gas (O2/CO2)	Gas analyser for OUR/CER	OPT
ORP / Redox	Digital ORP	OPT
Glucose / Lactate	PAT sensor	OPT

Utility	Typical service / configuration	Pressure	Flow / power	Notes
Electrical	EU base: 400 VAC / 50 Hz (3~)	N/A	AutoSIP: 12 kW; External SIP: 5 kW	NA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required
Process gases	Air / O2 / CO2 / N2	Up to 2.5 bar(g) (36.3 psi)	According to setpoint	Typical OD10 pneumatic connections; final list depends on package
Instrument air	Pneumatic valves	Up to 6 bar(g) (87.0 psi)	N/A	Dry/filtered air recommended
Cooling water	Jacket cooling water	2 bar(g) (29.0 psi)	25 L/min (6.6 gpm)	6-10 °C (43-50 °F) typical
Cooling water	Condenser cooling water	2 bar(g) (29.0 psi)	1 L/min (0.26 gpm)	6-10 °C (43-50 °F) typical
Steam (External SIP)	Industrial steam	2-3 bar(g) (29.0-43.5 psi)	30 kg/h (66 lb/h)	For SIP sequences
Steam (External SIP)	Clean steam	1.5 bar(g) (21.8 psi)	8 kg/h (18 lb/h)	Depending on plant strategy

Scope	EU (typical references)	North America (typical references)
Pressure equipment	PED 2014/68/EU	ASME BPVC Section VIII (where applicable)
Hygienic design	Hygienic design good practices	ASME BPE (reference for bioprocessing)
Machine safety	Machinery: 2006/42/EC (until 13/01/2027) / (EU) 2023/1230	OSHA expectations; NFPA 79 (industrial machinery) - project dependent
Electrical / EMC	LVD 2014/35/EU; EMC 2014/30/EU	NEC/NFPA 70; UL/CSA components and marking as required
Materials contact	EC 1935/2004 + EC 2023/2006 (GMP for materials) where applicable	FDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance
Software / CSV	EU GMP Annex 11 (if applicable)	21 CFR Part 11 (if applicable)

Tank model	Nominal volume	Minimum volume to start agitation*
Tank 50 L	50 L	15 L
Tank 100 L	100 L	20 L
Tank 200 L	200 L	30 L
Tank 500 L	500 L	55 L

Element	Operating pressure	Maximum pressure (safety)	Maximum working temperature
ePlus Mixer (control tower)	ATM	0.5 bar(g)	90 °C
Tank	ATM	0.5 bar(g)	45 °C
Jacket (if applicable)	N/A	1.5 bar	Depends on utilities / scope

Tangential flow filtration for lab, pilot and production

Multi Use Tangential Flow Filtration Systems

eLab TFF

ePilot TFF

eProd TFF

Single Use Tangential Flow Filtration Systems

eLab TFF SU

TFF platforms built around 4 core pillars

Scale

Membrane

Process step

Control

Multi Use TFF Systems

eLab TFF

ePilot TFF

eProd TFF

Single Use TFF Systems

eLab TFF SU

Download SUB Performance Report ⇀

Single-use consumables for TFF

Single-use consumables for bioreactors and mixing

Single-use bags for Tangential Flow Filtration Systems

eBag 2D Storage

eBag 2D TFF

Consult Our Sales team

Cellular configuration

Cellular configuration

Cellular configuration

Microbial configuration

Cellular configuration

Technical specifications

Materials and finishes

Design conditions

Pressure control and safeguards

Agitation

Integrated peristaltic pumps (additions)

Gas flow control (microbial reference capacity)

Instrumentation and sensors

Automation, software and connectivity

Utilities

Compliance and deliverables

Ordering and configuration

Cellular configuration

Technical specifications

Cellular configuration

Technical specifications

Models and working volumes

Design conditions and operating limits

Materials and finishes

Agitation system

Weighing and volume control

Pumps and fluid handling

Thermal management (optional jacket)

Instrumentation and sensors

Automation, software and data

Utilities and facility interfaces

Documentation and deliverables

Ordering and configuration

Cellular configuration

Scale

Bioreactors engineered for smooth scale-up

From S to XL, with a clear scale path

Operating windows microbial vs. cell culture

Indicative operating windows for cellular and microbial processes. Final values depend on bag configuration, impellers, aeration strategy and process targets.

Typical gas line ranges by model and application. Installed ranges and gas setup depend on selected options and project scope.