Maximize research and production results with Pilot Scale Bioreactor

Pilot scale bioreactor with leading technology and flexibility

Optimizing bioprocessing outcomes with innovative engineering and precise regulation.

The ePILOT® is made of stainless steel AISI 304 and 316L. It is a crucial tool in upstream processes, providing exceptional productivity in both cell culture and microbial fermentation. Its design, crafted to meet diverse client demands, prioritises efficient culture growth and offers various vessel sizes for seamless scale-up productions.

Integrating a PLC into our bioreactor improves bioprocessing success by providing flexible programming, ensuring a comprehensive understanding of each stage of the process.

Our pilot scale bioreactor features advanced monitoring systems. These systems enable the real-time tracking of crucial parameters like pH, pO2, temperature, and foam levels. This tracking ensures ideal conditions for the growth and development of cells and microorganisms.

Maximizing bioprocessing efficiency with pilot scale bioreactor

Modular vessel design

Advanced control system

Precision monitoring

Sterilization capabilities

Optimised agitation system

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Key strategies for effective scalability in pilot scale bioreactors

TECNIC ePILOT® bioreactor offers a unique solution in scalability and adaptability, allowing for the interchangeability of vessels¹ between the cellular and microbial versions. Essential for laboratories and production plants, seeking flexibility in their cell culture and microbial fermentation processes.

With working volumes of 10, 20, 30, and 50 liters, the interchangeable vessels of the ePILOT® facilitate the transition between different scales of production or research, without the need to invest in multiple systems. The bioreactor is dedicated to precision and adaptability, with real-time monitoring through integrated sensors.

Key components include: external jacket, sparger, overlay gas inlets, rupture disc, addition valves, and ports for sensors, sampling kit, a bottom valve and a front-integrated sight glass allows monitoring of crucial parameters like turbidity and agitation.

Vessels for Cell Culture

stainless steel cell culture vessel of pilot scale bioreactor

stainless steel microbial culture vessel of pilot scale bioreactor

The cellular version of our ePILOT® is an advanced system designed to optimize cell culture, offering unprecedented flexibility and efficiency for cellular applications. With working volumes of 10, 20, 30, and 50 liters and interchangeable vessels, the ePILOT® seamlessly adapts to diverse research, development, and production needs.

This configuration encompasses comprehensive control of critical parameters vital for optimal cellular growth, including pH, temperature, dissolved oxygen, and foam. The jacketed vessel, available in a double-wall option, is equipped with a 2x pitched-blade impeller, its agitation features precisely governed by a Servomotor. Additionally, to further elevate functionality, the system can be augmented with optional features such as a microsparger for finer bubble generation and an AUTO SIP version for autonomous sterilization.

Vessels for Microbial Culture

The microbial version of our ePILOT® bioreactor boosts the efficiency and flexibility of microbial fermentation processes. It ensures optimal growth conditions and process control for microbial applications. Equipped with interchangeable vessels, the pilot scale microbial bioreactor easily adapts to various scales, from small-scale research to larger production batches. Its advanced control systems and precise monitoring capabilities enable meticulous management of fermentation parameters, assuring high-quality outcomes.

It features a jacketed vessel and includes a Servomotor that controls three 6-blade Rushton impellers, providing superior mixing and aeration essential for effective microbial growth and product formation. The system can be upgraded with options like a microsparger for finer bubble generation, a dip pipe sparger for efficient gas delivery, AUTO SIP version, and off-gas analysis to fine-tune the cultivation environment.

Our range of bioreactors

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198x335x200 Sizes (mm) 5 Weight (kg) 0,5 · 1 · 2 · 5 Volumes (L) Aluminium Housing material - Scalable Multi use Single use Vessels Borosilicate glass PP & PA 12 Vessel material eOS - Software Sensors pH Dissolved O₂ Temperature sensor Foam / Level sensor External balance - - - - - - - 4x fixed speed - Peristaltic pumps Brushless 250 Motor (W)	460x817x550 Sizes (mm) 60 Weight (kg) 1 · 2 · 5 · 10 Volumes (L) Stainless steel Housing material Up to 12 vessels Scalable Multi use Single Use Vessels Borosilicate glass Stainless steel Vessel material eSCADA Advanced eSCADA R&D Software Sensors pH Dissolved O₂ Temperature sensor Foam / Level sensor External balance Total cell density Viable cell density pCO₂ ORP (Redox) Off-gas analyzer - - 8x variable speed - Peristaltic pumps Servomotor 400 Motor (W)	1200x2020x910 Sizes (mm) - Weight (kg) 10 · 20 · 30 · 50 Volumes (L) Stainless steel Housing material Interchangeable vessels Scalable Multi use - Vessels Borosilicate glass Stainless steel Vessel material eSCADA Advanced eSCADA R&D Software Sensors pH Dissolved O₂ Temperature sensor Foam / Level sensor External balance Total cell density Viable cell density pCO₂ ORP (Redox) Off-gas analyzer Pressure sensor - 4x variable speed - Peristaltic pumps Servomotor 400-750 Motor (W)	≈4455x6198x5125 Sizes (mm) - Weight (kg) 100 - 4000 Volumes (L) Stainless steel Housing material - Scalable Multi use - Vessels Borosilicate glass Stainless steel Vessel material eSCADA Advanced eSCADA R&D Software Sensors pH Dissolved O₂ Temperature sensor Foam / Level sensor External balance Total cell density Viable cell density pCO₂ ORP (Redox) Off-gas analyzer Pressure sensor - 2x variable speed 2x fixed speed Peristaltic pumps Asynchronous 190-19.000 Motor (W)